Platelet aggregation collagen induced

Itazigrel (137) is an antithrombotic compound because of its inhibition of platelet aggregation induced by collagen. It is synthe.sizcd froin l-bromo-l-(4-methoxy)benzoyl-4-methoxytol-uene (135) by reaction in the usual way with triflucffothioacetamide (136) to give itazigrel 471. 

As a typical example of a 6-heteroarylsubstituted dihydropyridazinone exhibiting antithrombotic activity motapizone, NAT 05-239 (63) (CAS 90697-57-7) may serve [96], Compound CCI 17810 (64) (CAS 76283-03-9) bearing a substituted phenyl moiety at C-6 of the pyridazine system has been shown to inhibit potently in vitro human platelet aggregation (induced by collagen, ADP, thrombin or arachidonic acid) with EC50 values in the range of 0.5-10/rg/ml [245], ... 

Platelet Inhibition Ginger extract has been found to inhibit platelet aggregation induced by arachidonic acid, epinephrine, ADP, and collagen (Srivastava 1984). The extract s ability to inhibit cyclooxygenase activity and thromboxane levels correlated well with inhibition of platelet aggregation (Srivastava 1984 Mustafa et al. 1993). The type of preparation used also affects platelet inhibition, because roasted and charcoal of ginger were effective, while ether extracts of raw and dried ginger were not (Wu et al. 1993). 

Platelets aggregation stimulation. Fruit juice, administered intravenously by infusion to dogs at a dose of 5 mL/min, was active. Total infusion was 300 mL h Oil, administered orally to six New Zealand white rabbits fed a commercial diet supplemented with 60 g/kg of coconut oil low in all PUFA for 60 days, produced a platelets aggregation induced by both thrombin and collagen significantly lower with either fish or linseed oil (n-3 PUFA), than with corn oil (n-6 PUFA) or the low PUFA coconut oil . 

Glaucine was shown to exhibit an inhibitory action on blood platelet aggregation induced by collagen, arachidonic acid, and ADP in vitro [266]. 

Protopine was found to dose-dependently inhibit in vitro rabbit platelet aggregation induced by ADP, arachidonic acid (AA), collagen, or aggregoserpentin of Trimeresurus... 

Many papers have been published reporting the serine protease inhibitory activity of amidine or diguanide derivatives (see chapter 21 of this volume). A series of aromatic amidine compounds was reported to inhibit platelet aggregation induced by ADP, collagen and thrombin. The most active compound was (30).lOO... 

Several studies have explored the anti-platelet effect produced by naturally occurring quinones. For example, the quinone fraction isolated from Auxemma oncocalyx (Allem/Eo) is a reversible and concentration-dependent inhibitor of human platelet aggregation induced by ADP, arachidonic acid, collagen and thrombin [298], Zhang et al. [299] studied the antiplatelet effects of 2-chloro-3-(4-acetophenyl)-amino-l,4-naphthoquinone. This... 

We observed recently that a relatively high concentration (300 pM) of phthalide 20 in rat PRP significantly inhibited platelet aggregation induced by collagen but not by ADP and U-46619 (a thromboxane A2 receptor agonist) [299]. The inconsistency between the previously reported data and our results may be due to the different species (rat versus rabbit) and preparations (platelet-rich plasma versus washed platelets) used. 

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