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Immune response characteristics

Antigen-induced, non immune response-related gene expression changes Immune response characteristics on gene expression level at 6 and 13 months, respectively ... [Pg.474]

Functional subpopulations of Th cells are distinguished by discrete cytokine secretion profiles. While both populations in mice produce granulocyte/ macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3), only Thl cells secrete interferon - / (TFN - 7) and interleukin-2 (IL-2) and only Th2 cells produce interleukins-4, 5, 6 and 10 (IL-4, IL-5, IL-6 and IL-10) (Mosmann and Coffman, 1989 Mosmann et al., 1991). Consistent with the proposal that chemical contact and respiratory allergens provoke in mice immune responses characteristic of selective Thl- and Th2-type activation, respectively, it has been... [Pg.123]

Unlike infection by other retroviruses, HIV Infection eventually kills host cells, causing the defects In the Immune response characteristic of AIDS. [Pg.143]

Infliximab (remicade, cA2) is a chimeric immunoglobulin (25% mouse, 75% human) that binds to and neutralizes TNF-a, one of the principal cytokines mediating the Tjjl immune response characteristic of Crohn s disease see Figure 38-1). [Pg.659]

The most commonly used animal model to study GAS pharyngitis is the mouse upper respiratory tract infection model (14,15,16). However, mice do not develop a true pharyngitis and only a relatively few animals become colonized even when high concentrations of inocula are used. Moreover, in our experience the data obtained with this model are poorly reproducible, and because the blood volume of the mouse is small the ability to easily perform many standard immunologic assays is limited. In addition, several gas virulence factor do not act on mouse molecules. Therefore, the relevance, significance, and usefulness of the murine model of GAS pharyngitis is limited. Several independent studies indicate that non-human primates may provide a more suitable model to study GAS pharyngitis animals are successfully colonized by GAS, and limited data indicate that the infections mimicked the humoral immune response characteristic for human disease (70,77,75,79,20). [Pg.256]

In addition to the wasting of muscle tissue, loss of intestinal mucosa, and impaired immune responses seen in marasmus, children with kwashiorkor show a number of characteristic feamres. The defining characteristic is edema, associated with a decreased concentration of plasma proteins. In addition, there is enlargement of... [Pg.479]

Idiotypic network. Idiotypic determinants (idiotypes) are unique antigenic epitopes characteristic of the antigen receptors on the surface of T and B cells. They are associated with the variable regions of these receptors. Antibodies produced by B cells as the result of antigenic stimulation can themselves stimulate the production of auto-anti-idiotypic antibodies which have the ability to combine with the B-cell receptor (Ig) and thus can dampen down the immune response. Idiotypes may likewise stimulate the production of T cells specific for idiotypic determinants. Jerne (1974) postulated his... [Pg.296]

Details on the cellular immune responses occurring following the recognition of xenobiotic haptens as antigens by the immune system are described in chapters 33-35 of this volume. Ultimately, a certain combination of mediators is selectively activated and subsequently helps determine and differentiate the characteristic immune response (e.g., Thl vs. Th2). For example, dermal sensitizing chemicals (e.g., oxazolone and dinitrochlorobenzene) elicit a higher proportion of Thl cytokines such as IFNy and... [Pg.55]


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