Ibuprofen gel

Ibuprofen, an acidic drug, which has a pAia of 4.4, is analysed by chromatography ph ODS silica gel with a mobile phase consisting of acetonitrile/0.1 M acetate buffer pH 4.2 (40 60). 

A liquid gel preparation of ibuprofen, 400 mg, provides prompt relief and good overall efficacy in postsurgical dental pain. 

In addition to the above-discussed parameters, other factors such as dimension of the column, particle size of the silica gel, and mobile phase additives may be considered for the optimization of chiral resolution on these CSPs. Metal ions often are important structural components in some proteins to organize conformation [112]. Therefore, the effect of metal ions as mobile phase additives may be useful. Oda et al. [74] used zinc ions as the mobile phase additive on avidin CSP to improve the chiral resolution of ibuprofen, chlormezanone, and other drugs. The results are summarized in Table 5, which indicates that the addition of zinc ions in the mobile phase has resulted into an improved resolution of some... 

Oral ibuprofen is often prescribed in lower doses (< 2400 mg/d), at which it has analgesic but not anti-inflammatory efficacy. It is available over the counter in low-dose forms under several trade names. A topical cream preparation appears to be absorbed into fascia and muscle an (S)( ) formulation has been tested. Ibuprofen cream was more effective than placebo cream for the treatment of primary knee osteoarthritis. A liquid gel preparation of ibuprofen 400 mg provided faster relief and superior overall efficacy in postsurgical dental pain. In comparison with indomethacin, ibuprofen decreases urine output less and also causes less fluid retention than indomethacin. Ibuprofen has been shown to be effective in closing patent ductus arteriosus in preterm infants, with much the same efficacy and safety as indomethacin. Oral ibuprofen is as effective as intravenous administration in this condition. 

PGs produced in the gastric mucosa stimulate the secretion of both bicarbonate and the mucus gel to protect the mucosa from damage by gastric secretions. Use of NSAIDs, such as aspirin and ibuprofen, reduces the production of the prostanoids and so decreases the protection of the gastric mucosa, promoting mucosal erosion. 

Several NSAIDs have topical preparations, for example ibuprofen (Ibugel), diclofenac (Voltarol emulgel), piroxicam (Feldene gel) and ketoprofen (Oruvail gel). The objective is to produce therapeutic local concentrations without (undesirable) systemic... 

In addition to aspirin and Cciffeine the most common components of analgesics are, at present, acetaminophen and ibuprofen (Notrin). Phenac-etin, the P of the APC tablet and a former component of Empirin, has been removed from the market because of deleterious side effects. In addition to one or more of these substances, each tablet contains a binder, often stcu-ch or silica gel. And to counteract the acidic properties of aspirin an inorganic... 

Polyacrylamide forms water-based gels at concentrations around 4%w/v, which exhibit pseudoplastic behavior. A PAAm ophthalmic gel containing pilocarpine was compared with other gel vehicles the ocular bioavailability for the PAAm gel was three times greater than that of the aqueous control solution. The kinetics of ibuprofen release for crosslinked PAAm gels was studied. A kinetic model was proposed for swelling induced loading of insulin into crosslinked PAAm gels. ... 

PEG 400 solubilizes 200 mg of ibuprofen in over-the-counter liquid gel-caps Advil Migrane and Liqui-Gels for a fast onset of action. PEG 400 has the highest solubilization power for ibuprofen and was selectively higher for the active S-isomer compared to the R-isomer (Nerurkar et al., 2005). 

A mixture of PEG 400 and medium-chain triglycerides solubilizes 200 mg of ibuprofen and 30 mg of pseudoephedrine in over-the-counter liquid Advil Cold Sinus liquid gel-caps. 

Goto, S. Kawata, M. Suzuki, T. Kim, N.-S. Ito, C. Preparation and evaluation of Eudragit gels. I. Eudragit organogels containing drugs as rectal sustained-release preparations. J.Pharm.Sci., 1991, 80, 958—961 [rabbit plasma ibuprofen (IS) pharmacokinetics]... 

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