Hypotensive drug beta-blocker

Drug interactions Proleukin may affect central nervous system function. Therefore interactions could occur following concomitant administration of psychotropic drugs. Concurrent administration of drugs possessing nephrotoxic, myelotoxic, cardiotoxic, or hepatotoxic effects with Proleukin may increase toxicity in these organ systems. Reduced kidney and liver function secondary to Proleukin treatment may delay elimination of concomitant medications and increase the risk of adverse events from those drugs. Beta-blockers and other antihypertensives may potentiate the hypotension seen with Proleukin. 

PROSTAGLANDINS -ALPROSTADIL ANTIHYPERTENSIVES AND HEART FAILURE DRUGS, BETA-BLOCKERS, CALCIUM CHANNEL BLOCKERS, NITRATES t hypotensive effect Additive hypotensive effect Monitor BP at feast weekly until stable. Warn patients to report symptoms of hypotension (light-headedness, dizziness on standing, etc.)... 

Older patients with CHF may be faced with multiple therapies of diuretics, ACE inhibitors/angioten-sion II blockers and beta-blockers. This puts them at risk of hypotension, orthostatic hypotension, azo-taemia and electrolyte imbalance. Drugs should be added carefully, starting at low dose and patients should be monitored for volume depletion and changes in serum creatinine and electrolyte concentrations. 

Direct vasodilators frequently produce baroreflex-induced tachycardia, but rarely orthostatic hypotension. They are usually prescribed with a beta blocker or a centrally acting antihypertensive to minimize the reflex increase in heart rate and cardiac output. It should be noted that another member of the directly acting class of antihypertensives is minoxidil. This potent, long-acting drug has gained considerable notoriety for its use as a topical hair-restorer. Oral use can result in hirsutism (unwanted hair growth over the face as well as other parts of the body). 

BETA-BLOCKERS ANTIPARKINSON S DRUGS - LEVODOPA t hypotensive effect Additive hypotensive effect however, overall, adding beta-blockers to levodopa can be beneficial (e.g. by reducing the risk of dopamine-mediated risk of arrhythmias) Monitor BP at least weekly until stable... 

BACLOFEN, TIZANIDINE 1. ANAESTHETICS - general 2. ANTICANCER AND IMMUNOMODULATING DRUGS - IL-2 3. ANTIDEPRESSANTS - MAOIs 4. ANTI HYPERTENSIVES AND HEART FAILURE DRUGS 5. ANTI-PSYCHOTICS 6. ANXIOLYTICS AND HYPNOTICS 7. BETA-BLOCKERS 8. CALCIUM CHANNEL BLOCKERS 9. DIURETICS 10. NITRATES 11. PERIPHERAL VASODILATORS-moxisylyte (thymoxamine) 12. POTASSIUM CHANNEL ACTIVATORS t hypotensive effect Additive hypotensive effect. Tizanidine also has a negative chronotropic effect and may cause additive bradycardia with beta-blockers and calcium channel blockers Monitor BP at least weekly until stable. Warn patients to report symptoms of hypotension (light-headedness, dizziness on standing, etc.)... 

OESTROGENS 1. ANTIHYPERTENSIVES AND HEART FAILURE DRUGS 2. BETA-BLOCKERS 3. CALCIUM CHANNEL BLOCKERS 4. NITRATES f hypotensive effect Oestrogens cause sodium and fluid retention Monitor BP at least weekly until stable the routine prescription of oestrogens in patients with t BP is not advisable... 

Drugs that are metabolized by the cytochrome P-450 (CYP) isoenzymes CYP2D6, CYP2C9, and CYP2C19 also exhibit genetic polymorphisms. An example of CYP2D6 metabolism is debrisoquine. In about 5-10 /o of Caucasians in North America and Europe and about 1% of Asians, 4-hydroxylation of debrisoquine is reduced, and such individuals are at increased risk for toxicity (orthostatic hypotension). Beta blockers (metoprolol and timolol), antiarrhythmic drugs (encainide and flecainide), tricyclic antidepressants... 

Beta blockers Increased levels of both drugs, hypotension... 

The primary clinical effects observed in beta blocker toxicity are cardiovascular in nature. Direct cardiac effects include bradycardia (sinus, atrioventricular node, and ventricular), all degrees of atrioventricular block, bundle branch blocks, and asystole. Ventricular arrhythmias may occur secondary to bradycardia. Torsades de pointes has been associated with chronic toxicity from sotalol. Hypotension occurs and is due to decreased cardiac output and/or vasodilation. Central nervous system effects of these drugs including lethargy, coma, and seizures are secondary to the cardiovascular toxicities. Seizures and coma may be secondary to hypoglycemia. Bronchospasm can occur secondary to beta-2 blockade. Hypoglycemia and hyperkalemia can occur. 

B. Toxicodynamics Toxicodynamics is a term used to denote the injurious effects of toxins, ie, their pharmacodynamics. A knowledge of toxicodynamics can be useful in the diagnosis and management of poisoning. For example, hypertension and tachycardia are typically seen in overdoses with amphetamines, cocaine, and antimuscarinic drugs. Hypotension with bradycardia occurs with overdoses of calcium channel blockers, beta-blockers, and sedative-hypnotics. Hypotension with tachycardia occurs with tricyclic antidepressants, phenothiazines, and theophylline. Hyperthermia is most frequently a result of overdose of drugs with antimuscarinic actions, the salicylates, or sympathomimetics. Hypothermia is more likely to occur with toxic doses of ethanol and other CNS depressants. Increased respiratory rate is often a feature of... 

---