Heart failure drugs

US Food and Drug Administration (2005). FDA approves BiDil heart failure drug for Black patients. Press Release, June 23, 2005. www.fda.gov/bbs/topics/NEWS/2005/NEW01190.html [Accessed October 4,2005]. 

Ertl G. Endothelin receptor antagonists in heart failure. Drugs 2004 64 1029-40. 

Feenstra J, Grobbee DE, Mosterd A, Strieker BHCh. Adverse cardiovascular effects of NS AIDs in patients with congestive heart failure. Drug Saf 1997 17(3) 166-80. 

Sunirinib (Sutent) [Kinase Inhibitor] Uses Advanced GI stromal tumor refractory/intolerant of imatinib advanced RCC Action Kinase inhibitor Dose Adults. 50 mg PO daily x 4 wk, followed by 2 wk holiday = 1 cycle 4- to 37.5 mg w/ CYP3A4 inhibitors (Table VI-8), to T 87.5 mg w/ CYP3A4 inducers Contra w/ atazanavir Caution [D, -] Multiple interactions require dose modification (eg, St. John s wort) Disp Caps SE -l WBC pit, bleeding, T BP, -l ejection fraction, T QT interval, pancreatitis, DVT, Sz, adrenal insuff, N/V/D, skin discoloration, oral ulcers, taste perversion, hypothyroidism Interactions Multiple interactions require dose modification (eg, St. John s wort) EMS Monitor ECG for T QT interval grapefruit juice may T adverse effects may affect potassium level (hypo-/hyperkalemia) monitor for S/Sxs of heart failure drug can 4- ejection fraction OD May cause abd pain, muscle weakness, and chills symptomatic and supportive... 

ALISKIREN ANTIHYPERTENSIVES AND HEART FAILURE DRUGS-ANGIOTENSIN II RECEPTOR ANTAGONISTS Aliskiren levels possibly 1 by irbesartan. Risk of hyperkalaemia Uncertain Monitor BP at least weekly until stable... 

PROCAINAMIDE ANTI HYPERTENSIVES AND HEART FAILURE DRUGS-ACE INHIBITORS Possible T risk of leukopenia Uncertain at present Monitor FBC before starting treatment, 2-weekly for 3 months after initiation of therapy, then periodically thereafter... 

CARDIOVASCULAR DRUGS ANTIHYPERTENSIVES AND HEART FAILURE DRUGS ACE inhibitors and other drugs... 

Primary drug Secondary drug Effect ANTIHYPERTENSIVES AND HEART FAILURE DRUGS Mechanism Precautions... 

ANTI HYPERTENSIVES AND HEART FAILURE DRUGS ALBUMIN-CONTAINING SOLUTIONS Acute 1 BP following rapid infusion with captopril or enalapril Uncertain at present Use alternative colloids monitor BP closely while on infusion... 

ANTI HYPERTENSIVES AND HEART FAILURE DRUGS ALCOHOL 1. Acute alcohol ingestion may t hypotensive effects 2. Chronic moderate/ heavy drinking 1 hypotensive effect 1. Additive hypotensive effect. 2. Chronic alcohol excess is associated with hypertension Monitor BP closely as unpredictable responses can occur. Advise patients to drink only in moderation and avoid large variations in the amount of alcohol drunk... 

ANTIHYPERTENSIVES AND HEART FAILURE DRUGS ANAESTHETICS-GENERAL Risk of severe hypotensive episodes during induction of anaesthesia Most general anaesthetics are myocardial depressants and vasodilators. Additive hypotensive effect Monitor BP closely, especially during induction of anaesthesia... 

ANTI HYPERTENSIVES AND HEART FAILURE DRUGS NS AIDs 1 hypotensive effect, especially with indometacin. The effect is variable amongst different ACE inhibitors and NSAIDs, but is most notable between captopril and indometacin NSAIDs cause sodium and water retention and raise BP by inhibiting vasodilating renal prostaglandins. ACE inhibitors metabolize tissue kinins (e.g. bradykinin) and this may be the basis for indometacin attenuating hypotensive effect of captopril Monitor BP at least weekly until stable. Avoid co administering indometacin with captopril... 

ANTIHYPERTENSIVES AND HEART FAILURE DRUGS ANTI HYPERTENSIVES AND HEART FAILURE DRUGS t hypotensive effect. Episodes of severe first dose 1 BP when alpha-blockers are added to ACE inhibitors Additive hypotensive effect may be used therapeutically Monitor BP at least weekly until stable, particularly on initiation of therapy. Consider starting therapy at night... 

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