Hypotension with

During initial therapy, headache and postural hypotension may occur, and the nurse must notify the primary health care provider because a dose change may be necessary. The nurse assists patients having episodes of postural hypotension with all ambulatory activities. The nurse instructs those with episodes of postural hypotension to take the drug in a sitting or supine position and to remain in that position until symptoms disappear. Hypotension maybe accompanied by paradoxical... 

In an anesthetized, ventilated canine model of anaphylactic shock defined as hypotension with blood pressure maintained at 50% of baseline, epinephrine infusion produces an improvement in blood pressure, associated with positive inotropy [21]. 

Treat hypotension with fluids and vasopressor support. 

Generally, arblockers are considered as second-line agents to be added on to most other agents when hypertension is not adequately controlled. They may have a specific role in the antihypertensive regimen for elderly males with prostatism however, their use is often curtailed by complaints of syncope, dizziness, or palpitations following the first dose and orthostatic hypotension with chronic use. The roles of doxazosin, terazosin, and prazosin in the management of patients with hypertension are limited due to the paucity of outcome data and the absence of a unique role for special populations or compelling indications from JNC 7. 

Titrated up to 75-100 mcg/minute until relief of symptoms or limiting side-effects (headache or hypotension with a systolic... 

Rituxan) hypotension with or without a steroid to alleviate infusion-related reactions. Rate of infusion should be increased gradually to minimize reactions. 

Lung Cancer Etoposide (VP-16) -plant alkaloid, topoisomerase II inhibitor -bone marrow suppression -nausea and vomiting -mucocutaneous effects (mucositis, stomatitis)—increased at higher doses -chemical phlebitis common -hypotension with rapid administration -hypersensitivity reactions -secondary leukemia... 

Adverse effects include postural hypotension with associated CNS symptoms, reflex tachycardia, headaches and flushing, and occasional nausea. Excessive hypotension may result in MI or stroke. Noncardiovascular adverse effects include rash (especially with transdermal nitroglycerin) and methemoglobinemia with high doses given for extended periods. 

Treat hypotension with IV fluids or colloid replacement, and consider use of a vasopressor such as dopamine. 

Pronounced bradycardia with a beta blocker pronounced hypotension with an angiotensin II receptor antagonist... 

Anaphylactic reactions including fatal anaphylaxis other hypersensitivity reactions including dyspnea, urticaria, other rashes, and febrile episodes inflammation at or near injection site, including sterile abscesses (IM) brown skin discoloration at injection site (IM) flushing and hypotension with overly rapid IV administration ... 

Hypotension Hypotension (postural) occurs regularly in about 50% of patients while they are supine, manifested by dizziness, light-headedness, vertigo, or faintness. Tolerance occurs unpredictably but may be present after several days. Hypotension with supine systolic pressure above 75 mm Hg need not be treated unless symptomatic. If supine systolic pressure falls below 75 mm Hg, infuse dopamine or norepinephrine to increase blood pressure use dilute solution and monitor blood pressure closely because pressor effects are enhanced by bretylium. Perform volume expansion with blood or plasma and correct dehydration where appropriate. Transient hypertension and increased frequency of arrhythmias Transient hypertension and increased frequency of arrhythmias may occur due to initial release of norepinephrine from adrenergic postganglionic nerve terminals. 

Other adverse cardiovascular and respiratory effects Orthostatic hypotension, with or without syncope, can occur with clozapine treatment. Rarely, collapse can be profound and accompanied by respiratory and/or cardiac arrest. Orthostatic hypotension is more likely to occur during initial titration in association with rapid dose escalation. In patients who have had even a brief interval off clozapine, start treatment with 12.5 mg once or twice daily (see Warnings). Because collapse, respiratory arrest, and cardiac arrest during initial treatment have occurred in patients receiving benzodiazepines or other psychotropic drugs, caution is advised when clozapine is initiated in patients taking a benzodiazepine or any other psychotropic drug. 

Hypotension - Orthostatic hypotension with or without syncope can occur, especially during initial titration in association with rapid dose escalation, and may represent a continuing risk in some patients. Garefully watch those undergoing surgery, and those who are on large doses of phenothiazines for hypotensive phenomena. The hypotensive effects may occur after the first injection of the antipsychotic, occasionally after subsequent injections, and rarely after the first oral dose. 

Potentially severe adverse effects can result from systemic administration of cholinomimetic drugs, and none should be administered by intramuscular or intravenous injection. If significant amounts of these drugs enter the circulation, nausea, abdominal cramps, diarrhea, salivation, hypotension with reflex tachycardia, cutaneous vasodilation, sweating, and bronchoconstric-tion can result. Pilocarpine can cross the blood-brain barrier and affect cognitive function. Even the topical application of cholinomimetics to the eyes can present... 

Too-rapid IV administration may produce marked hypotension with accompanying faintness, light-headedness, palpitations, tachycardia, hyperventilation, nausea, vomiting, angina-like pain, seizures, ventricular fibrillation, and cardiac standstill. 

Overdose may produce excessive peripheral vasodilation and marked hypotension with reflex tachycardia. 

First-dose syncope (hypotension with sudden ioss of consciousness) may occur 30 to 90 min foiiowing initiai dose of 2 mg or greaf er, a f oo-rapid increase in dosage, or addif ion of anof her anf ihyperfensive agenf f o f herapy. First-dose syncope may be preceded by tachycardia (puise rate of i20-i60 beafs/minute). 

Of particular importance in the geriatric patient Delirium, confusion, cognitive impairment, amnesia, sedation, lethargy, ataxia, hypotension (with IV), osteomalacia,... 

Alcohol Theories include combination of effects at receptor and Pi adernergic agonism leading to GABA receptor sensitization to ethanol Sedation and hypotension with coadministration Caution patients to avoid coadministration Lin et al., 1994... 

It is characterized by severe, persisting pain, shock and hypotension with possible development of arrhythmias and is due to severe depression of systolic cardiac performance, systolic arterial pressure is below 80 mm Hg, low cardiac index, ventricular filling pressure is elevated and pulmonary edema may or may not be evident. The most frequent cause is infarction involving more than fourty percent of the left ventricular myocardiam, leading to a severe reduction in left ventricular contractility contradictively and failure of the left ventricular pump. 

Adverse effects include marked hypotension with first dose of terazosin, drowsiness, dizziness, nausea, blurred vision, nasal congestion, peripheral edema, syncopal episodes and headache. In patients with BPH postural hypotension has been reported more than in those with hypertension. 

Hypersensitivity, sulphite allergy, excessive hypotension with disopyramide. Incompatible with dextrose and frusemide (furosemide). 

Fukusaki M et al Effects of controlled hypotension with sevoflurane anesthesia on hepatic function of surgical patients. Eur J Anaesthesiol 1999 16 111. [PMID 10101627]... 

Prazosin, doxazosin, and terazosin are all efficacious in patients with BPH. These drugs are particularly useful in patients who also have hypertension. Considerable interest has focused on which -receptor subtype is most important for smooth muscle contraction in the prostate subtype-selective K1A-receptor antagonists might lead to improved efficacy and safety in treating this disease. As indicated above, tamsulosin is also efficacious in BPH and has relatively minor effects on blood pressure at a low dose. This drug may be preferred in patients who have experienced orthostatic hypotension with other -receptor... 

Benzisoxazole Risperidone Broad efficacy little or no extrapyramidal system dysfunction at low doses Extrapyramidal system dysfunction and hypotension with higher doses... 

Marked hypotension with circulatory collapse has occasionally been reported with desmopressin (20,21), although both of these reports related to patients with pre-existing cardiac conditions. 

Hoeldtke RD, Horvath GG, Bryner KD, Hobbs GR. Treatment of orthostatic hypotension with midodrine and octreotide. J Clin Endocrinol Metab 1998 83(2) 339-43. 

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