Insecticides toxicodynamics

Bradbury, S.P. and J.R. Coats. 1989b. Toxicokinetics and toxicodynamics of pyrethroid insecticides in fish. Environ. Toxicol. Chem. 8 373-380. 

Vale, J. A. (1998). Toxicokinetic and toxicodynamic aspects of organophosphate (OP) insecticide poisoning. Toxicol. Lett. 102-103, 649-652. 

In summary, the chemical structure of the OP pesticide and the presence of other ingredients in the formulation may have an impact on the speed of onset of features of intoxication. In addition, the fact that many OP insecticides are lipophilic means that they arc distributed to and stored in body fat, and therefore elimination takes place slowly. Thus, the severity of intoxication may increase for 12-36 hr after exposure, intoxication may be prolonged, or relapse may occur after apparent clinical recovery. An understanding of the toxicodynamic aspects also explains why oximes may be of particular value in intoxication due to diethyl phosphates. 

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