Hypoglycemia reaction

Hypogiycemic reactions Hypoglycemia when using this concentrated insulin can be prolonged and severe. As with other human insulin preparations, hypoglycemia reactions may be associated with the administration of concentrated insulin. However, deep secondary hypoglycemic reactions may develop 18 to 24 hours after the original injection of concentrated insulin. 

Notify the physician if abdominal or chest pain, dark urine or light stool, hypoglycemia reactions, fever, nausea, palpitations, rash, vomiting, or yellowing of eyes or... 

Generally, the untoward effects associated with tola2amide are the same as those noted with the other sulfonylureas the incidence is low and reactions are reversible when tola2amide is discontinued. Hypoglycemia has been reported occasionally. 

Sulfaphenazole (684) and sulfazamet (685) are both examples of relatively short acting sulfonamides (B-80MI40406) and their antibacterial activity has been tested against Escherichia coli, the former being more effective than the latter. Sulfaphenazole also displaces sulfonyl ureas from protein binding sites on human serum albumin and consequently increases the concentration of the free (active) drug and produces a more intense reaction that may result in hypoglycemia. 

More than half of the patients receiving this drug by the parenteral route experience some adverse reaction. Severe and sometimes life-threatening reactions include leukopenia (low white blood cell count), hypoglycemia (low blood sugar), thrombocytopenia (low platelet count), and hypotension (low blood pressure). Moderate or less severe reactions include changes in some laboratory tests, such as the serum creatinine and liver function tests. Other adverse reactions include anxiety, headache, hypotension, chills, nausea, and anorexia Aerosol administration may result in fatigue a metallic taste in the mouth, shortness of breath, and anorexia... 

Acetaminophen causes few adverse reactions when used as directed on the label or recommended by the primary health care provider. Adverse reactions associated with the use of acetaminophen usually occur with chronic use or when the recommended dosage is exceeded. Adverse reactions to acetaminophen include skin eruptions, urticaria (hives), hemolytic anemia, pancytopenia (a reduction in all cellular components of the blood), hypoglycemia, jaundice (yellow discoloration of the skin), hepatotoxicily (damage to the liver), and hepatic failure (seen in chronic alcoholics taking the drug). 

Seizure disorders are generally categorized as idiopathic or acquired. Idiopathic seizures have no known cause acquired seizure disorders have a known cause, including high fever, electrolyte imbalances, uremia, hypoglycemia, hypoxia, brain tumors, and some drug withdrawal reactions. Once the cause is removed (if it can be removed), the seizures theoretically cease. 

SYMPTOMS HYPOGLYCEMIA (INSUUN REACTION) HYPERGLYCEMIA (DIABETIC COM A, KETOACIDOSIS)... 

D Confusion related to adverse drug reaction (hypoglycemia)... 

The nurse should check the patient for hypoglycemia (see Table 49-1) at the peak time of action of the insulin (see Summary Drug Table Insulin Reparations). Hypoglycemia, which can develop suddenly, may indicate a need for an adjustment in the insulin dosage or other changes in treatment, such asa change in diet. Hypoglycemic reactions can occur at any time but are most likely to occur when insulin is at its peak activity. 

The nurse notifies the health care provider of any hypoglycemic reaction, die substance and amount used to terminate the reaction, blood samples drawn (if any), the length of time required for die symptoms of hypoglycemia to disappear, and die current status of the patient. After termination of a hypoglycemic reaction, the nurse closely observes die patient for additional hypoglycemic reactions. The lengtii of time close observation is required depends on die peak and duration of the insulin administered. 

Anorexia, nausea, vomiting, epigastric discomfort, heartburn, hypoglycemia Anorexia, nausea, vomiting, epigastric discomfort, heartburn, diarrhea, hypoglycemia, allergic skin reactions... 

Adverse reactions associated with the administration of tiie meglitinides include upper respiratory infection, headache, rhinitis, bronchitis, headache, back pain, and hypoglycemia... 

Know the symptoms of hypoglycemia and hyperglycemia and the health care provider s method for terminating a hypoglycemic reaction. 

Unwanted effects. Hypoglycemia results from absolute or relative overdosage (see p. 260). Allergic reactions are rare—locally redness at injection site, atrophy of adipose tissue (lipodystrophy) systemically urticaria, skin rash, anaphylaxis. Insulin resistance can result from binding to inactivating antibodies. A possible local lipohypertrophy can be avoided by alternating injection sites. 

Adverse reactions occurring in at least 3% of patients include the following diarrhea, dizziness, dyspepsia, feeling jittery, headache, hypoglycemia, nausea, vomiting. 

Human insulin Hypoglycemia and hypokalemia are among the potential clinical adverse reactions associated with the use of all insulins. Other adverse reactions... 

Gl disturbances (eg, nausea, epigastric fullness, heartburn) are the most common reactions. Other adverse reactions may include hypoglycemia, disulfiram-like reactions allergic skin reactions eczema pruritus erythema urticaria photosensitivity reactions leukopenia thrombocytopenia aplastic anemia agranulocytosis hemolytic anemia pancytopenia weakness paresthesia tinnitus fatigue dizziness vertigo malaise elevated liver function tests. 

Adverse reactions that occurred in at least 3% of patients included the following Aggravated diabetes mellitus, edema, headache, hypoglycemia, myalgia, pharyngitis, sinusitis, tooth disorder, upper respiratory tract infection. 

The answer is C. Pyruvate kinase deficiency is ruled out by the elevated serum lactate levels. The coma is associated with a fasting hypoglycemia, which is indicative of pyruvate carboxylase deficiency. The elevated citrulline and lysine in the serum are due to a reduction of aspartic acid levels, which are caused by the reduced levels of oxaloacetate, the product of the pymvate carboxylase reaction. 

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