Hyperthermal

Engel T 1996 Fundamental aspects of the reaction of thermal and hyperthermal F, F2, Cl, and CI2 with Si surfaces Japan. J. Appl. Phys. 35 2403-9... 

Signs and symptoms of sympathetic nervous system activity are invariably found in MH. Levels of catecholamines are markedly increased in MH. Whether activation of the sympathetic nervous system is a primary or a secondary response in the syndrome has not been fully elucidated. Gronert reported that stress-induced sympathetic hyperactivity can initiate a malignant hyperthermic episode in susceptible swine without a triggering agent. Stress-induced MH in humans has been inferred because susceptible families have been shown to have an increased incidence of sudden death. Gronert s reasons that activation of the sympathetic... 

The large disparity between nuclear and electron masses has another important effect. For thermal or hyperthermal energies up to about 10,000 eV,... 

Supersonic molecular beam (SMB) mass spectrometry (SMB-MS) measures the mass spectrum of vibra-tionally cold molecules (cold El). Supersonic molecular beams [43] are formed by the co-expansion of an atmospheric pressure helium or hydrogen carrier gas, seeded with heavier sample organic molecules, through a simple pinhole (ca. 100 p,m i.d.) into a 10 5-mbar vacuum with flow-rates of 200 ml. rn in. In SMB, molecular ionisation is obtained either through improved electron impact ionisation, or through hyperthermal surface ionisation... 

Hyperthermal surface ionisation (HSI) is an ultrasensitive tuneable selective ion source [222,223] which is based on the very effective ionisation of various hyperthermal molecules upon their scattering from a surface with a high work function, such as rhenium oxide. Molecule-surface electron transfer constitutes the major and most important HSI mechanism for GC-MS. 

MDMA (Ecstasy) No clinical uses, although it has been used for psychotherapy recreational use widespread acute hyperthermic problems midweek depression during neurochemical depletion long-term problems include neurotoxicity, memory/cognitive deficits and a range of psychiatric problems. 

Miksic, S. et al., Acquisition and extinction of a conditioned hyperthermic response to a tone paired with morphine administration, Neuropsychobiology 1, 211,1975. 

Cyclic analogs of DMT and DET, i.e, 43 and 44, respectively, have been synthesized the aziridine 43 appears to possess activity as a CNS depressant (171), while the pyrrolidine 44 displays some behavioral activity. Compound 44 was active in Hall s open-field test but was less active than DET (38) (23). In attempts to measure hyperthermic activity, 44 was found to be rather toxic in rabbits (111). Oddly enough, no cyclic analog has ever shown activity/potency comparable to its acyclic counterpart. Thus, based only on scant animal data, cyclization of the lower dialkyl homologs apparently does not lead to marked behavioral activity. 

Brimblecombe, R. W. (1967) Hyperthermic effects of some tryptamine derivatives in relation to their behavioral activity. Int. J. Neuropharmacoi, 6 423-429. 

To confirm their results and check for methodological problems, some studies have been carried out. As there was a probability that hypothermic conditions during temporary removal from dam may have affected the results, Pauluhn and Schmuck administered S-bioallethrin and deltamethrin to neonatal mice from postnatal day 10 to 16 under a hypo-, normo-, or hyperthermic environment, and measured the MAChR density at the age of 17 days [51]. Increase in MAChR in Cortex at PND 17 in animals treated with S-bioallethrin was observed. Meanwhile, no changes were observed in animals treated with deltamethrin. In addition, an enormous influence of environmental temperature on the density of MAChR receptors in the crude synaptosomal fraction of the cerebral cortex was ascertained. Tsuji et al. exposed mouse dams with their litters to D-allethrin by inhalation for 6 h from postnatal day 10 to 16. The inhalation administration method is the most relevant route of exposure for humans, including babies and infants, after indoor use of D-allethrin. The neonatal exposure to D-allethrin by inhalation did not induce effects either on the brain MAChR density or motor activity at 17 days and 4 months of age, or on performance in the leaming/memory test at 11 months of age [52]. Other unpublished studies with D-allethrin, S -bioallethrin, or deltamethrin were examined to confirm the results of Eriksson et al. and showed inconsistent results [53]. The reasons for discrepancy among these findings are unknown. 

Keywords Carbon Nanotubes, Fullerenes, Hyperthermic, Chemoperfusion, Cancer... 

IPHC, Intraperitoneal hyperthermic chemoperfusion/chemotherapy MMC, Mitomycin C IP, Intraperitoneal SOD, Superoxide dismutase Nd YAG, Neodymium-doped yttrium aluminium garnet Nd Y3A15012 NIR, Near infrared FITC, Fluorescein isothiocyanate PEG, Polyethylene glycol FA, Fohc acid CDDP, Cisplatin TEM, Transmission electron microscopy... 

Fig. 10.8 Effect of various hyperthermic temperatures on colorectal cancer cells. Temperatures above 42°C are the most effective for cell killing (Reprinted from Hildebrandt et al., 2002. With permission from Elsevier)...

Fig. 10.9 Circuit diagram for intraperitoneal hyperthermic chemoperfusion. Warmed chemotherapeutic agents are circulated through the abdomen and temperature at the inflow and outflow ports are continuously monitored (Reprinted from Reingruber et al., 2007. With permission from Elsevier) (See Color Plates)... 

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