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5-hydroxytryptamine receptors, design

Serotoninergic System. Figure 1 Graphical representation of the current classification of 5-hydroxytryptamine (5-HT) receptors. Receptor subtypes represented by shaded boxes and lowercase designate receptors that have not been demonstrated to definitively function in native systems. Abbreviations 3-5r cyclic adenosine monophosphate (cAMP) phospholipase C (PLC) negative (-ve) positive (+ve)... [Pg.1123]

Nowhere is the need for specificity so great as in trying to design therapies for the human brain. Here there are numerous receptors that affect our moods, sleep, alertness, memory, and coordination. Even though the importance of serotonin (5-hydroxytryptamine, 5-HT) had been known to neuroscientists for over 100 years, it wasn t until the discovery of drugs... [Pg.110]

Lopez-Rodriguez ML, Vicente B, Deupi X, et al. Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(la) receptor ligands to explore the three-dimensional structure of the receptor. Mol Pharmacol 2002 62 15-21. [Pg.57]

See other pages where 5-hydroxytryptamine receptors, design is mentioned: [Pg.198]    [Pg.246]    [Pg.222]    [Pg.92]    [Pg.43]    [Pg.162]   
See also in sourсe #XX -- [ Pg.12 ]



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