Hydrochloride Nasal Solution

OXYMETAZOLINE HYDROCHLORIDE NASAL SOLUTION 15ML SPRAY BOTTLE 6505008694177 BT 4.16 ... 

Dose. Cyclopentamine hydrochloride has been used as a 0.5 or 1% nasal solution. It has been given in doses of 25 mg intramuscularly, or 5 to 10 mg intravenously. 

Berger W, Abelson MB, Gomex PJ. Effects of adjuvant therapy with 0.1% olopatadine hydrochloride ophthalmic solution on quaUty of life in patients with aUergic rhinitis using systemic or nasal therapy. Ann AUergy Asthma Immunol 2005 95 361-371. 

R. Pereira-Rosario, S. El-Gizaway, J.H. Perrin and C.M. Riley, Analysis of Nasal Solutions Containing Phenylephrine Hydrochloride and Pheniramine Maleate by High Performance Liquid Chromatography on a Cyclodextrin Bonded Stationary Phase and Diode Array Spectrophotometry, Drug Dev. Ind. Pharm., 12(14)(1986)2443. 

Cocaine hydrochloride aqueous solutions. Adult dose up to 4% (ophthalmology). Solutions up to 10% are applied to the nasal mucosa (otolaryngological procedures). Maximum total adult dose recommended for use on the nasal mucosa is 1.5 mg/ kg in order to avoid risk of arrhythmias. 

Cocaine hydrochloride is a water-soluble salt that can be injected or absorbed by any mucosal membrane (eg, nasal snorting). When heated in an alkaline solution, it is transformed into the free base, "crack cocaine," which can then be smoked. Inhaled crack cocaine is rapidly absorbed in the lungs and penetrates swiftly into the brain, producing an almost instantaneous "rush."... 

Astelin nasal spray contains 0.1% azelastine hydrochloride in an aqueous solution at pH 6.8 0.3. It also contains benzalkonium chloride (125 mcg/mL), edetate disodium,... 

Fill in plastic bottles that are closed with a conventional spray insert or into plastic or glass bottles that are closed with a conventional pump sprayer. In the latter case, pumps with nasal spray inserts are, for example, used that spray about 0.14 mL of solution per actuation. In this manner, 0.14 mg of azelastine hydrochloride is sprayed into the nose per actuation in the form of the solution. 

Selegiline hydrochloride Semduramycin sodium Serenda repcus, serenovarepens Sertraline hydrochloride Sevoflurene inhalation Sibutramine hydrochloride Sildenafil citrate Silymarin Simvastatin Sodium enoxaparin Sodium picosulfate Solution/nasal spray/injection... 

Fig. 2 Disappearance profiles of (A) tetrahydrozoline hydrochloride and (B) chlorpheniramine maleate from rat nasal cavity after nasal administration of an o/w emulsion and an aqueous solution at pH 8. (From Ref. l)...

Smoking the base alkaloid (as crack or freebase) and nasal insufflation of the hydrochloride salt are the most common routes of exposure in abuse. Intravenous injection and application of the hydrochloride salt to mucous membranes are also methods of abuse. In therapeutic use, a solution of hydrochloride salt is applied to mucous membranes. 

SCHIFF (1941) refers to a similar case in which a patient received a series of intramuscular injections of 25 mg dosages within a period of 7 months using three different commercial preparations. After the last injection, nausea, vomiting, profuse sweating, and collapse occurred showing the signs of severe shock. On closer interrogation, it was found that the patient had had several brief episodes of nasal symptoms and nausea after the previous injections. An intradermal test with an aqueous solution of thiamine hydrochloride was also positive in this case. In view of the rapidity with which the reaction occurred, the author assumed that some of the thiamine hydrochloride solution must have been administered intravenously at the last injection. 

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