Hydrocarbons benzo pyrene

Sander and wise have proposed a test method to determine the bonding chemistry used to prepare octadecylsiloxane column packings based on the relative retention of three polycyclic aromatic hydrocarbons, benzo[a]pyrene (BaP), phenanthro-phenanthrene (PhPh), and l,2 3,4 5,6 7,8-tetrabenzonaphthalene (TBN) eluted with the mobile phase acetonitrile-water (85 15) [52,67,199,210]. On monomeric phases the test solutes elute in the... 

Brunstrom, B. 1986. Activities in chick embryos of 7-ethoxycoumarin O-deethylase and aryl hydrocarbon (benzo[a]pyrene) hydroxylase and their induction by 3,3, 4,4 -tetrachlorobiphenyl in early embryos. Xenobiotica 16 865-872. 

Hose, J.E. and H.W. Puffer. 1984. Oxygen consumption rates of grunion (Leuresthes tenuis) embryos exposed to the petroleum hydrocarbon, benzo[a]pyrene. Environ. Res. 35 413-420. 

Wiebel, F. J., Leutz, J. C., Diamond, L., and Gelboin, H. V. Aryl hydrocarbon (benzo[a]pyrene) hydroxylase in microsomes from rat tissues differential inhibition and stimulation by benzoflavones and orqanic solvents. Arch. Biochem. Biophys. (1971) 144 78-86. 

Initial studies designed to obtain a valid subcellular fractionation scheme for rainbow trout liver illustrated the aryl-hydrocarbon (benzo[a]pyrene] hydroxylase activity separated with glucose-6-phosphatase (35). This observation indicated that the trout hemoprotein P-450-mediated monooxygenation system was located within the endoplasmic reticulum (microsomal fraction). 

Fig. 5 Typical deformations detected in 96 hpf zebrafish embryos exposed at the indicated concentrations of the carcinogenic polycyclic aromatic hydrocarbons Benzo[a]Pyrene (b) and Benazo [k]Fluoranthene (c), or to the reportedly nontoxic AhR-ligand (3-naphthofiavone (d). A nonexposed, normal specimen is shown in (a). Arrows indicate (a) pericardial edema, (b) malformation of the lower jaw, (c) malformation of the tail, (tf) color of the yolk, and (e) coagulation...

Maximum residue levels in certain foods are set for the following contaminants nitrate, my cotoxins (aflatoxins, ochratoxin A, pamlin, deoxynivalenol, zearalenone, fumonisins, T -2 and HT-2-toxin), metals (lead, cadmium, mercury, inorganic tin), 3-MCPD (3-monochloro-propane-l,2-diol), dioxins and PCBs, and polycyclic aromatic hydrocarbons (benzo(a)pyrene) (EC 2007c). 

A1 Planar polyaromatic hydrocarbons (PAHs) Benzo[ ] pyrene 1-Ethynyl pyrene TCDD, PAHs Many PAHs... 

Huberman, E. and Sachs, L. (1966). Cell susceptibility to transformation and cytotoxicity by the carcinogenic hydrocarbon benzo[a]pyrene, Proc. Natl. Acad. Sd. 56,1123,... 

Other cycloadditions of interest include the photoaddition [Eq. (52)] of pyrimidine derivatives such as cytosine to the carcinogenic hydrocarbon benzo[a]pyrene,191 and the photoaddition of allene as a vital step [Eq. (53)] in the synthesis of an annotinine derivative.192... 

Polynuclear aromatic Anthracene, hydrocarbons benzo(a)pyrene... 

Formation of a dihydrodiol by hydration of epoxide groups can be an important detoxication process in that the product is often much less reactive to potential receptors than is the epoxide. However, this is not invariably the case because some dihydrodiols may undergo further epoxidation to form even more reactive metabolites. As shown in Figure 7.3, this can happen with benzo(a)pyrene 7,8-epoxide, which becomes oxidized to carcinogenic benzo(a)pyrene 7,8-diol-9,10-epoxide. The parent polycyclic aromatic hydrocarbon benzo(a)pyrene is classified as a procarcinogen, or precarcinogen, in that metabolic action is required to convert it to a species, in this case benzo(a)pyrene 7,8-diol-9,10-epoxide, which is carcinogenic as such. 

L. L. Shipman, in Polynuclear Aromatic Hydrocarbons, R. Freudenthal and P. W. Jones, Eds., Raven Press, New York, 1976. Ab Initio Quantum Mechanical Characterization of the Ground Electronic State of Benzo[ ]pyrene. Implications for the Mechanism of Polynuclear Aromatic Hydrocarbon Oxidation to Epoxides by Cytochrome P-450. 

Metabolization of the polycyclic aromatic hydrocarbon benzo[a]pyrene by a non-white rot fungus (Fusarium solani) in a batch reactor. Polycyclic Aromatic Compounds, 22, 87-97. 

Polycyclic aromatic hydrocarbons Benzo(a)pyrenes Methylcholanthrene Dimethylbenz(a)anthracene Solvents Benzene Heavy metals Beryllium Manganese Nickel Cadmium Platinum Air pollutants Ozone... 

Pentachlorophenol (PCP) absorption in porcine skin was tripled when exposure to PCP was preceded by preexposure to the lipophilic polynuclear aromatic hydrocarbon benzo[a]pyrene.]15l... 

Colpa et al. (1963) calculated p/ (S )-values for a series of aromatic hydrocarbons, but could not detect fluorescence changes in the regions of acidity indicated by the Forster cycle, although fluorescence spectra attributed to proton complexes of 3,4-benzo-pyrene and 1,2-benzanthracene were observed in some solutions containing only the neutral molecule in the ground state. Flurry and co-workers (1963, 1966, 1967) have carried out theoretical and Forster cycle calculation on the excited state basicities of poly-methylbenzenes and Kuz min et al. (1967) have also calculated p/sT(S1)- and p7 (T )-values for polycyclic aromatic hydrocarbons increases in base strength of from 7 to 30 powers of ten were derived for Sj. 

At low temperatures, in situations where there is relatively little 02, pyrolysis reactions (i.e. reactions where decomposition takes place as a result of heat) may cause a rearrangement of atoms that can lead to the formation of polycyclic aromatic hydrocarbons (see Section 2.7) during combustion. The most notorious of these is benzo[ ]pyrene (B[ ]P see Fig. 2.4), a cancer-inducing compound. 

Polycyclic aromatic hydrocarbons DMBA (dimethylbenzanthracene), BaP (benzo[ ]pyrene), MCA (methylcholanthrene) ... 

Bos RP, Theuws JL, Leijdekkers Ch. M. 1984b. The presence of the mutagenic polycyclic aromatic hydrocarbons benzo[a]pyrene and benz[a]anthracene in creosote Pj. Mutat Res 130 153-158. 

Being interested here in the volatile components of coffee aroma, we shall arbitrarily limit the list of the aromatic hydrocarbons to tricyclic structures. The higher fused polycyclic hydrocarbons (fluoranthene [206-44-0], pyrene [129-00-0], chrysene [218-01-9], benz[ ]anthracene (1,2-benzanthracene) [56-55-3], benz[< ]acephenanthrylene (3,4-benzofluoranthene) [205-99-2], benzo[ ]pyrene (3,4-benzopyrene, 3,4-BP) [50-32-8], benzo[e]pyrene (1,2-benzopyrene) [192-97-2], perylene [198-55-0], benzo[g,/i,/]perylene (1,12-benzopyrene) [191-24-2], and dibenz[ ,//]anthracene (1,2,5,6-dibenzanthracene) [53-70-3]) cannot be considered as a part of the aroma. However, as some of these, specially benzo[o pyrene, are known for carcinogenic properties, they have been particularly analyzed in food subject to roasting or smoke-curing. 

Effect of polycycbc hydrocarbons in vitro on aryl hydrocarbon (benzo[a]pyrene) hydroxylase Biochem. 

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