Ethynyl pyrene

A1 Planar polyaromatic hydrocarbons (PAHs) Benzo[ ] pyrene 1-Ethynyl pyrene TCDD, PAHs Many PAHs... 

Leroy-Lhez S, Pages F. Synthesis and photophysical properties of a highly fluorescent ditopic ligand based on l,6-bis(ethynyl)pyrene as central aromatic core. Eur J Org Chem 2005 2005 2684-8. 

Diring S, Camerel F, Donnio B, Dintzer T, Toffanin S, Capelli R, Muccini M, Ziessel R. Luminescent ethynyl-pyrene liquid crystals and gels for optoelectronic devices. J Am Chem Soc 2009 131 18177-85. 

Ethynylpyrene (Scheme 13) was the first analog of benzo(a)pyrene that was tested as an inhibitor of benzo(a)pyrene hydroxylase. This ethynyl polycyclic aromatic hydrocarbon (PAH) is a very potent in vitro suicide inhibitor of cytochrome P450 lA mediated oxidations of The inhibitory property has been attributed to the drug s fitting... 

Structure-activity relationship studies of ethynyl-PAH compounds (Scheme 13) showed that, while all compounds that were tested were competitive inhibitors of cytochrome P450 1 A, only very few analogs inhibited the enzyme in a mechanism-based fashion. Thus, while methyl-1-pyrenylacetylene and 3-ethynylperylene are suicide inhibitors of benzo(a)pyrene hydroxylation, phenyl-1-pyrenylacetylene is only a competitive inhibitor . ... 

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