Detoxication process

The elemental homeostasis is the particularity of total homeostasis of organism, the alteration of the parameters of this system may result in pathological changes. The liver is the organ where the detoxication processes take place. The elemental content of the liver may reflect the pathological processes which occur not only in the liver but also in the whole organism. 

While the enzymes involved in detoxication processes are nonspecific in the classical sense of intermediary metabolism, they often have distinct specificities both for organic functional groups and for the electronic, steric, and stereochemical environments where these functional groups are located. Enzyme specificity based on organic functional groups and their environments leads to a wide diversity in the alkaloid substrates possible and therefore the products obtained from biotransformation. This section of the chapter will concentrate principally on the enzymes themselves, including general concepts of substrate specificity and mechanism. 

Following a single dose of mercuric chloride to rats, mercury also tended to accumulate with time after injection in the Iysosome-peroxisome group of particles [47]. This accumulation may represent a detoxication process [48]. 

Calu-3 cells have shown the ability to perform fatty acid esterification of budes-onide [132], In pre-clinical studies, this esterification results in a prolonged local tissue binding and efficacy, which is not found when the esterification is inhibited [133]. The precise mechanism remains undefined in that the identity of specific enzyme(s) responsible for this metabolic reaction is unclear [134], Assessment of the potential toxicity and metabolism of pharmaceuticals and other xenobiotics using in vitro respiratory models is still at its infancy. The development of robust in vitro human models (i.e., cell lines from human pulmonary origin) has the potential to contribute significantly to better understanding the role of biotransformation enzymes in the bioactivation/detoxication processes in the lung. 

Biflavanoids in vegetables and fruits play a vital role in the storage of ascorbic acid in leukocytes, in the core of adrenal glands and in other organs. It also causes more effective expenses under ascorbic acid s deficiency in the organism. Phenolic compounds present in the organism, activate detoxication processes in the liver. The flavanoids exceed the tocopherols and carotenoids in terms of antioxidant effect. 

As in the case of propachlor mercapturic acid sulfoxide, the biological significance of xenobiotic mercapturic acids that contain oxidized sulfur is not known. Casida et al. (39) have reported that sulfoxidation of some thiocarbamate herbicides is a beneficial step in the detoxication process. However, cysteine conjugates can exhibit adverse biological activities. Smith (40) has reviewed work on the metabolism of the toxic principle in kale and has shown that C-S lyase action on S-methylcysteine sulfoxide produces the toxic principle. Virtanen ( ) has reviewed the processes in other plants that lead to the production of compounds with biological activity from -substituted cysteine sulfoxides. 

T0291 EnviroSource Technologies, Inc., Super Detox Process... 

T0201 Delta Cooling Towers, Inc., Aqua-Trim and Vanguard Air Strippers T0202 Detox Industries, Inc., DETOX Process... 

T0280 Environmental Research and Development, Inc., Ice Electrode T0285 Environmental Technology (U.S.), Inc., TR-Detox T0291 EnviroSource Technologies, Inc., Super Detox Process T0292 EnviroWall, Inc., EnviroWall Barrier... 

The process is applicable to sludges, sediments, and liquids and to in situ soil remediation. The DETOX process operates most effectively at soil temperatures between 60 and 95°F (16 and 35°C). The bioremediation process stops at soil temperatures below 32°F (0°C) and at soil temperatures above about 140°F (60°C). 

The DETOX process is no longer offered commercially by the developer, who filed for... 

The treatment costs using the DETOX process are substantially lower than those using traditional technologies such as incineration, landfill disposal, and alternative destructive technologies. Treatment costs for the process are equivalent to or less costly than nondestructive technologies such as encapsulation (D10163T, p. 2). 

EnviroSource Technologies Super Detox Process Abstract... 

According to the vendor, several factors of the Super Detox process limit processing costs. A low additive ratio reduces additive and disposal costs. The process has low energy requirements and can be custom designed for specific client needs (D15456N, p. 9). 

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