Hyaluronan binding proteins

Langner J Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis upregulation of hyaluronan-binding protein TSG-6. Arthritis Res Ther 2003 5 R186-R192. 

AJ Day. The structure and regulation of hyaluronan-binding proteins. Biochem Soc Trans 27 115-121, 1999. 

Stem et aL [149] made use of a hyaluronan-binding protein obtained from the tryptic digestion of the proteoglycan core protein of bovine nasal cartilage to detect hy alumni da sc activities in urine samples from wiles tumor patients. The pathophysiology of this tumor is associated with major alterations in the metabolism of hyaluiouan, and it is thought that urinary hyaluronidase can be used as an additional marker. 

Knudson, C.B. and Knudson, W., Hyaluronan-binding proteins in development, tissue homeostasis, and disease, FASEB J., 7, 1233, 1993. 

Melrose, J., Tammi, M., and Smith, S., Visualisation of hyaluronan and hyaluronan-binding proteins within ovine vertebral cartilages using biotinylated aggrecan Gl-link complex and biotinylated hyaluronan oligosaccharides, Histochem. Cell Biol., 2002 117, 327, 2002. 

Majumdar, M. et al., Hyaluronan binding protein 1 (HABPl)/ClQBP/p32 is an endogenous substrate for MAP kinase and is translocated to the nucleus upon mitogenic stimulation, Biochem. Biophys. Res. Commun., 291, 829, 2002. 

Turley, E.A. (1989) The role of a cell-associated hyaluronan-binding protein in fibroblast behaviour. In The Biology of Hyaluronan, Ciba Foundation Symposium 143, Wiley, Chichester, pp. 121-137. 

Abbreviations used BP, binding proteins ConA, Concanavalin A GNA, snowdrop lectin HA, hemagglutinin HyBP, hyaluronan-binding protein MBP, mannose-binding protein SAP, serum amyloid Pcoinionent SBA, soybean a lutinin var, variable WGA,... 

Yang, B., Yang, B. L., Savani, R. C., and Turley, E. A. (1994). Identification of a common liyal-uronan binding motif in the hyaluronan binding proteins RHAMM, CD4 and link protein. The EMBO Journal 13, 286-296. 

The receptor for HA endocytosis had been found on the membrane of endothelial cells of the liver sinuses and fundamentally differs from other hyaluronan-binding proteins (see [13] and references therein). 

Austel, C.C., Nure, E.A., Vandelig, K. (1991) Hyaluronan and cell-associated hyaluronan binding protein regulate the locomotion of ras-transformid cells. Journal of Cell Biology, 112 (5), 1041-1047. 

Early work on embryonic development and tissue repair suggested strongly that hyaluronan influences cell behavior. Consequently, evidence was sought and obtained for the presence of hyaluronan-binding proteins on the surface of cells [16, 17]. Subsequent investigations led to the full molecular characterization of two classes of cell surface hyaluronan receptors, namely CD44 and RHAMM. Numerous reviews (e.g. [10-12, 18, 19]) have been published that amply describe work on the structures and functions of CD44 and RHAMM and this work will only be summarized here. 

A third and, as yet, puzzling group of proteins appears to be emerging, i.e. intracellular hyaluronan-binding proteins. These include Cdc37 [25], P-32 [26], LH21... 

Another unusual hyaluronan-binding protein is inter-a-trypsin inhibitor [30]. This serum protein is composed of a light ehain, also known as bikunin, and two heavy chains which are covalently cross-bridged by chondroitin sulfate. Hyaluronan can replace chondroitin sulfate by trans-esterification or bind non-covalently to the heavy chains. This interaction has been shown to bind hyaluronan to cell surfaces [30] and to participate in forming a matrix around the oocyte during ovulation [31, 32). 

Huang L, Grammatikakis N, Banerjee SD, Yoneda M, Toole BP. Molecular characterization of a novel hyaluronan-binding protein related to the intracellular Ki-1 antigen. Submitted for publication. 

Baneijee SD, Toole BP. Hyaluronan-binding protein in endothelial cell morphogenesis. J Cell Biol 1992 119 643-652. 

Levesque H, Girard N, Maingonnat C, Delpech A, Chauzy C, Tayot J, Courtois H and Delpech B. Localization and solubilization of hyaluronan and of the hyaluronan-binding protein hyaluronectin in human normal and arteriosclerotic arterial walls. Atherosclerosis 105 51-62, 1994. 

Ye L, Mora R, Akhayani N, Haudenschild CC and Liau G. Growth factor and cytokine-regulated hyaluronan-binding protein TSG-6 is localized to the injury-induced rat neointima and confers enhanced growth in vascular smooth muscle cells. Circ Res 81 289-96, 1997. 

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