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Structural Hyaluronan-Binding Proteins

AJ Day. The structure and regulation of hyaluronan-binding proteins. Biochem Soc Trans 27 115-121, 1999. [Pg.308]

Early work on embryonic development and tissue repair suggested strongly that hyaluronan influences cell behavior. Consequently, evidence was sought and obtained for the presence of hyaluronan-binding proteins on the surface of cells [16, 17]. Subsequent investigations led to the full molecular characterization of two classes of cell surface hyaluronan receptors, namely CD44 and RHAMM. Numerous reviews (e.g. [10-12, 18, 19]) have been published that amply describe work on the structures and functions of CD44 and RHAMM and this work will only be summarized here. [Pg.1787]

Interestingly, the secretion of FGF family members that mediate tissue repair resembles IL-1 secretion, that is, not involving the Golgi. The FGF family proteins also bind to their receptors by P-barrel structures that interact with a glycan (in this case known to be heparin) during activation. Hyaluronan and heparin are glycosaminoglycans (Sect. 6.3.1). [Pg.243]

See other pages where Structural Hyaluronan-Binding Proteins is mentioned: [Pg.1786]    [Pg.1787]    [Pg.1786]    [Pg.1787]    [Pg.1787]    [Pg.656]    [Pg.96]    [Pg.617]    [Pg.162]    [Pg.43]    [Pg.66]    [Pg.67]    [Pg.108]    [Pg.1066]    [Pg.1495]    [Pg.1828]    [Pg.58]    [Pg.1154]    [Pg.68]    [Pg.264]    [Pg.95]    [Pg.265]    [Pg.425]    [Pg.16]    [Pg.241]    [Pg.220]    [Pg.1504]    [Pg.16]    [Pg.24]    [Pg.54]    [Pg.61]    [Pg.62]    [Pg.65]    [Pg.104]    [Pg.161]    [Pg.173]    [Pg.184]    [Pg.1829]   


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Binding proteins structures

Binding structure

Hyaluronan

Hyaluronan binding proteins

Hyaluronane

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