Human lente insulin

Human Extended Insulin Zinc Suspension. Ultralente Humulin U is a long-acting form of human insulin produced by recombinant DNA techniques. It is adrninistered subcutaneously and should not be given intravenously. The time course of this preparation is similar for onset of activity but shorter for maximum activity and duration of action compared with ultralente preparations of animal origin. Insulins of the lente series can be mixed in any proportion to obtain the desired dose and modified activity. 

A 41-year-old woman became allergic to all types of insulin (beef, pork, human, lente, etc.). She had used insulin for the first time during pregnancy and was intermittently treated unsatisfactorily with oral agents. She used lispro insulin for more than 6 months without an allergic reaction. 

Human insulin from E coli is available for clinical use as Humulin (Lilly) and dispensed as either regular, NPH, lente, or ultralente Humulin. Human insulin prepared biosynthetically in yeast is marketed by Novo Nordisk as human insulin injection in regular, lente, and NPH forms Novolin R, Monotard Human Insulin (Novolin L), and Novolin N. The same company also produces a human insulin marketed as Velosulin (regular) that contains a phosphate buffer. This reduces aggregation of regular insulin molecules when used in infusion pumps. However, because of the tendency of phosphate to precipitate zinc ions, Velosulin should not be mixed with any of the lente insulins. 

Additionally, regular insulin will remain fast acting when combined with NPH but not when added to lente. The rapid action of regular insulin is neutralized by the excess zinc pre.sent in lente insulin. Similar products containing rDNA-derived human insulin (instead of the bovine- and porcine-derived insulin) are available. 

Insulin Zinc Suspension. Lente Insulin Lente lie-tin Insulin Novo Lente Human Monotard Insulin Ultra -card Lentard Monotard Semitard Ultratard. Sterile suspension, in a buffered water medium, of insulin modified by the addition of zinc chloride in a manner such that the solid phase of the suspension consists of a mixture of crystals and amorphous materia] in a ratio of approx 7 3 Hallas -Moller, Lancet 267, 1029 (1954). Contains 40 Or 80 U.S.P, insulin units/ml. Prepn of amorphous zinc insulin suspension Petersen et aL, U.S. pat, 2 82,203 (1959 to Novo Terapeu-tisk Lab. A IS). 

Lente insulin (insulin zinc suspension USP) Human, pork 8-12 18-24... 

Make any change of insulin cautiously and only under medical supervision. Changes in purity, strength, brand (manufacturer), type (eg, regular, NPH, lente), species (beef, pork, beef-pork, human), or method of manufacturer (rDNA vs animal-source insulin) may result in the need for a change in dosage. 

Novolin is available in four formulations Regular (R), NPH (N), Lente (L), and Novolin 70/30. They correspond to the several formulations of Humulin. Novolin 70/30, Novolin N, and Novolin R are supplied in prefilled cartridges and in prefilled disposable syringes. Velosulin BR is a sterile solution of human insulin (rDNA origin) in a phosphate buffer. 

Humulin (R, L, N, U, 50/50, and 70/30). Human insulin manufactured by Eli Lilly and Company has the trademark Humulin and is available in six formulations—Regular (R), NPH (N), Lente (L), Ultralente (U), 50% human insulin isophane suspension (NPH)/50% human insulin injection (buffered regular) (50/50), and 70% human insulin isophane suspension (NPH)/30% human insulin injection (buffered regular) (70/30). 

Regular insulin (human) is clear solution of zinc insulin. Its time of onset is 30-60 min with peak activity at 2-3 hand duration of 3-6 h. The widely used insulin NPH (neutral protamine Hagedom) is a suspension of zinc insulin co-crystallized with protamine and has a slower onset (2-4 h) with longer time to peak (4-lOh) and duration of action (10-16h). Insulin lente is a suspension of mixed amorphous and crystalline zinc insulin, with onset time of 3-4 h and a duration of 12-18 h. Insulin ultralente, which is a suspension of crystalline insulin with a high zinc content, is the slowest onset (6-10 h) and longest duration (18-20h) of these preparations. Peak plasma concentrations occur after about 10 h with insulin ultralente (36). 

USA human insulin Zn suspension insulin Humulin L Humulin Lente A mixture of crystalline and amorphous recombinant human insulin obtained from an E. coli expression system Diabetes... 

---