Scripps Research Institute

For developing osmium catalyzed oxidation methods for preparing chiral com pounds of high optical pu rity Professor K Barry Sharpless (Scripps Research Institute) shared the 2001 Nobel Prize in chemistry... 

This volume is based partly on the lecture notes of K. C. N. that were used for teaching courses at the University of Pennsylvania, the University of California, San Diego, and The Scripps Research Institute. We apologize sincerely to those whose brilliant works have been left out owing to the inevitable closing of the curtain and hope that in the event of a second volume we can rectify these omissions. We also apologize in advance for the inevitable errors that a volume of this size may contain, and welcome constructive comments from our readers in order to correct such errors in future editions. 

K. C. Nicolaou was bom in 1946 in Cyprus. He studied chemistry at the University of London (B.Sc., 1969 Ph.D., 1972), Columbia University (postdoctoral research) and Harvard University (postdoctoral research). Between 1976 and 1989 he was a faculty member at the University of Pennsylvania. He currently holds joint appointments at The Scripps Research Institute, where he is the Darlene Shiley Professor of Chemistry and Chairman of the Department of Chemistry, and at the University of California, San Diego, where he is Professor of Chemistry. His research interests span the areas of synthetic organic chemistry, bioorganic chemistiy, molecular design, and the chemistry and biology of natural products. 

Valery V. Fokin Department of Chemistry The Scripps Research Institute BCC-315... 

Professor D. Boger Scripps Research Institute La Jolla, CA, USA... 

Joel M. Gotteseeld Department of Molecular Biology The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 USA... 

K. C. Nicolaou s group at Scripps Research Institute developed two synthetic routes to epothilone A. One of the syntheses involves closure of the lactone ring as a late step. Three major fragments were synthesized. The bond connection at C(6)-C(7) was made by an aldol reaction. The C(12)-C(13) bond was formed by a Wittig reaction and later epoxidized. The ring was closed by macrolactonization. 

The scientific world was amazed to hear that David Lee, from the laboratory of Reza Ghadiri (Scripps Research Institute, La Jolla, California), had found a self-replicating peptide (Lee et al., 1996) there are analogies to the experiments with oligonucleotides (see Sect. 6.4). Lee was able to show that a certain peptide, containing 32 amino acids, can both function as a matrix and also support its own synthesis autocatalytically. The information transfer is clearly more complex than that involved in nucleic acid replication. In the case of this particular peptide, both the... 

The total synthesis of calicheamicin y/ by the research group of K. C. Nicolaou (The Scripps Research Institute, University of California, San Diego) represents a stunning achievement in synthetic organic chemistry. 

In 1980, K. B. Sharpless (then at the Massachusetts Institute of Technology, presently at the University of California San Diego, Scripps research Institute co-winner of the Nobel Prize for Chemistry in 2001) and co-workers reported the Sharpless asymmetric epoxidation . 

Zaragozic acid A (which is also called squalestatin SI and has been shown to lower serum cholesterol levels in test animals by inhibition of squalene biosynthesis) by K. C. Nicolaou (University of California San Diego, Scripps Research Institute) ... 

Dept, of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037... 

Flow Cytometry First Principles, 2nd Edition A.L. Given, Editor (Wiley-Liss, New York), 2001. www.cyto.purdue.edu ListServe (Hosted by The Purdue University Cytometry Laboratory), www.isac-net.org International Society for Analytical Cytology (IS AC). http //flowcyt.salk.edu Salk University. http //facs.scripps.edu/index/html Scripps Research Institute. http //science.cancerresearchuk.org/sci/facs Cancer Research UK. 

Anita Datta Scripps Research Institute and Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, California CA92307, USA... 

William A. Greenberg, Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd., La JoUa, CA 92307, USA... 

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