Leukemia HL-60 cells

Inayat-Hussain SH, Annuar BO, Din LB, Ali AM, Ross D. Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells. Toxicol In Vitro 2003 17 433-439. 

Inayat-Hussain SH, Annuar BO, Laily BD, Naoyuki T. Altholactone, a novel styryl-lactone induces apoptosis via oxidative stress in human HL-60 leukemia cells. Toxicol Lett 2002 131 153-159. 

Palozza, P., Serini, S., Torsello, A. et al. 2002b. Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells possible involvement of a redox mechanism. Int J Cancer 97 593-600. 

Kluza J, Mazinghien R, Irwin H, Hartley JA, Bailly C. (2006) Relationships between DNA strand breakage and apoptotic progression upon treatment of HL-60 leukemia cells with tafluposide or etoposide. Anti-Cancer Drugs 17 155-164. 

Aquino A, Hartman KD, Knode MC, Grant S, Huang KP, Niu CH, Glazer RI (1988) Role of protein kinase C in phosphorylation of vinculin in adriamycin resistant HL 60 leukemia cells. Cancer Res 48 3324-3329... 

Kluza, J., Mazinghien, R., Degardin, K., Lansiaux, A. and Badly, C. 2005. Induction of apoptosis by the plant alkaloid sampangine in human HL-60 leukemia cells is mediated by reactive oxygen species. European Journal of Pharmacology, 525(1-3) 32 0. 

Effects of Cephalotaxine Esters on HL-60 Leukemia Cell Differentiation and Inhibition of L-1210 In Vrntd ... 

In this study we investigated the activity of three acrylate monomers on HL-60 cells by examining of some functional parameters. Ours results clearly indicate that TEGDMA and Bis-GMA, in a dose-dependent manner, reduces cellular proliferation in HL-60 leukemia cell line. This antiproliferative effect of these monomers seems to depend on a cytostatic activity with a cytotoxic effect only at 0.6 and 0.775 mM concentrations. Moreover, the effect on cell proliferation appears higher than that observed with ATRA. HEMA, on the contrary, do not shows any effect on the cellular proliferation. All monomers induce the differentiation process of HL-60 cell line as indicated by the presence of CL activity which is strictly dependent on the appearance of respiratory burst in human myeloid tumour cell lines. 

Chao, P.D. et al.. Quercetin glucuronides inhibited 2-aminofluorene acetylation in human acute myeloid HL-60 leukemia cells, Phytomedicine, 9, 625,2002. 

Senthil, V., S. Ramadevi, V. Venkatakrishnan, et al. 2007. Withanolide induces apoptosis in HL-60 leukemia cells via mitochondria mediated cytochrome c release and caspase activation. Chem. Biol. Interact. 167 (l) 19-30. 

Mechanistic studies [35] showed combination treatments to inhibit cell proliferation via downregulation of cyclin D1 and induce apoptosis via activation of caspases-8 and -9 and downregulation of prosurvival proteins, FLIP and survivin [35]. Several stUhenes, related to resveratrol, have been synthesized and tested for their anticancer effect on HL-60 leukemia cell line, taking particular care of the cell cycle analysis. Figure 8.2 shows synthesis of stilbenes and its effects on cell cyde. A scheme of flow cytometry analysis of cell cycle is presented in Figure 8.3. The most potent compound was found to be (Z)-3,4, 5-trimethoxystilbene(I)... 

Kuroda M, Mimaki Y, Yokosuka A, Hasegawa F, Sashida Y (2002) Cholestane glycosides from the bulbs of Ornithogalum thyrsoides and their cytotoxic activity against HL-60 leukemia cells. J Nat Prod 65 1417-1423... 

Retinoid activities can also be modulated by the cellular retinoic acid-binding proteins (CRABPs) I and II. These proteins bind the natural retinoid trans-RA and potentiate its metabolic oxidation at the 4-position. ( )-4-[2-(3,5-Di-f-butylphenyl)propenyl]benzoic acid (CD55), which does not bind to CRABP and cannot be metabolized at its position corresponding to the 4-position of trans-RA, is far more potent than trans-RA in inducing the differentiation of HL-60 leukemia cells [43]. 

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