Histopathological injury

Schmidt, J., E. Ryschich, H. P. Sinn, S. Maksan, C. Herfarth, and E. Klar. 1999. Trypsinogen activation peptides (TAP) in peritoneal fluid as predictors of late histopathologic injury in necrotizing pancreatitis of the rat. Digestive Diseases and Sciences 44 823-829. 

ICH S7A lists examples of GI parameters that can be measured for example, gastric secretion, GI injury potential, bile secretion, transit time in vivo, ileal contraction in vitro, gastric pH, and pooling. The list of parameters is by no means comprehensive and s leans toward assessing function rather than histopathology this inclination reflects the distribution of clinical GI ADRs, but functional assessment should not predominate at the expense of histopathology. 

Miller, P. R., and L. S. Evans. Histopathology of oxidant injury and winter fleck injury on needles of Western pines. Phytopathology 64 801-806, 1974. 

Rats exposed to 5.4mg/m of the 54% chlorine compound for 7 hours daily for 4 months showed increased liver weight and injury to liver cells 1.5mg/m for 7 months also produced histopathologic evidence of liver damage, which was considered to be of a reversible character. The minimal lethal dose when the liquid was applied to the skin of rabbits was 1.5 g/kg. The vapor and the liquid are moderately irritating to the eye contact of the chemical with skin leads to removal of natural fats and oils, with subsequent drying and cracking of the skin. ... 

Blood, urine and histopathological analysis of rats and beagle dogs exposed by inhalation to 6-73.5 mg/m phenyl glycidyl ether for three months did not reveal any treatment-related effect. This compound caused skin irritation and corneal injury in rabbits and hair loss in rats. Its sensitizing potential in guinea-pigs is low (lARC, 1989). 

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