Histocompatibility locus

Yamaguchi, M., Yamazaki, K., Beauchamp, G.K., Bard, J., Thomas, L. and Boyse, E.A. (1981) Distinctive urinary odors governed by the major histocompatibility locus of the mouse. Proc. Natl. Acad. Sci. USA 78, 5817-5820. 

Type 1 diabetes affects approximately 1 in 200 Americans, with a sibling recurrence risk of about 6%. It is an example of an autoimmune disease (see Immunology Lecture Notes), in which self-reactive T cells infiltrate the pancreas to destroy insulin-produdng islet cells. Mutations in the class II major histocompatibility locus (MHC) region are estimated to contribute about one third of the risk of developing type 1 diabetes. Mutations in or near the insulin gene itself are responsible for another 10-15% of the risk. 

Prazak, J., Mericka, O., and Chytry, J. 1990. Histocompatibility locus antigens (HLA) in the epidermoid type of lung carcinoma. J. Cane. Res. Clin. Oncol. 116 525-521. 

Williams RM, Moore MJ Linkage of susceptibility to experimental allergic encephalomyelitis to the major histocompatibility locus in the rat. J Exp Med 1973 138 775-83. 

Mb, Megabase(s), or millions of base pairs MHC, Major Histocompatibility locus MMTV, Mouse Mammary Tumour Virus MoMLV, Moloney Murine Leukemia Virus MuLV, Murine Leukemia Virus Mya, Million(s) years ago Myr(s), Million year(s)... 

The products of the major histocompatibility locus have been shown to interact with viral antigens on the cell surface of thymocytes. A number of polypeptides bind to the major envelope glycoprotein of Rauscher murine leukaemia virus. The receptors for this glycoprotein, which probably involve lipoproteins, have been prepared from plasma membrane preparations from mouse cells. ... 

Table 4.3 Inheritance of specific Ir genes and of the major histocompatibility locus of strain 2 and strain 13 guinea pigs by (2 x 13)Fi and backcross animals...

THE ROLE OF PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY LOCUS IN CELLULAR INTERACTIONS WHICH REGULATE IMMUNE RESPONSES... 

Figure 4.8 Failure of physiological cooperative interactions to occur in vivo between T and B lymphocytes differing at the major histocompatibility locus. The scheme followed is described in text. Recipients for all cell combinations were (A x B10)Fi hybrids. Combinations and strain origins of T and B cells and the relevant genetic differences are indicated. Recipients in groups I—VIII were secondarily challenged with 50 pg of DNP—BGG. Mean serum anti-DNP antibody levels of groups of five mice on day 7 after secondary challenge are illustrated. Horizontal bars represent ranges of the standard error. (Taken from reference 64.)...

The gene for ADA has been tentatively assigned to chromosome 20 so that there is no linkage with the major histocompatibility locus, assigned to chromosome 6 in man. There is an independent assortment of HL-A haplotypes and ADA deficiency in families with infants affected with severe combined immunodeficiency. Thus, it appears likely that the ADA deficiency has a causal relationship to severe combined immunodeficiency and that lymphoidal stem cells may be particularly vulnerable to the consequences of the absent or abnormal ADA. 

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