Mouse mammary tumour virus

Calberg-Bacq, C.-M. Francois, C., Gosselin, L., Osterrieth, P. M. and Rentier-Delrue, F. 1976. Comparative study of the milk fat globule membrane and the mouse mammary tumour virus prepared from the milk of an infected strain of Swiss albino mice. Biochim. Biophys. Acta 419, 458-478. 

Fig. 5. Specificity of steroid response element. A. In this example (mouse mammary tumour virus), the element will bind receptors for glucocorticoids (G), androgen (A), progestin (P) and mineralocorticoid (M) so that each of these classes of steroid stimulate transcription. This type of specificity can vary from cell to cell possibly due to other protein factors (not shown). B. Although oestrogen (E) receptor will not act as an agonist for mouse mammary tumour virus transcription, it may antagonise the agonist activity of glucocorticoids (G).

It has now been found that the glucocorticoid response elements of mouse mammary tumour virus and the gene for chicken lysozyme also bind progesterone re-... 

As pointed out above, nt1 receptors have been discovered in lymphoma cells selected for resistance to the cytolytic glucocorticoid effect. Since receptors from which the M domain had been eliminated by cDNA manipulation still function to some extent in transfection studies it was important to find out whether nt1 receptors would also be able to mediate some hormonal response. This was in fact observed when nt lymphoma variants were transfected with a DNA construct consisting of the LTR region of the mouse mammary tumour virus coupled to the gene for chloramphenicol acetyltransferase (U. Gehring and H. Losert, unpublished experiments). Hormonal induction of enzyme activity was consistently observed but was low, as one might expect. 

Mb, Megabase(s), or millions of base pairs MHC, Major Histocompatibility locus MMTV, Mouse Mammary Tumour Virus MoMLV, Moloney Murine Leukemia Virus MuLV, Murine Leukemia Virus Mya, Million(s) years ago Myr(s), Million year(s)... 

Using an indirect immunoperoxidase technique an antigen, immunologically related to a glycoprotein of mouse mammary tumour virus, has been identified in sections of human breast cancer. Cross-reactivity between the human and murine antigens is due to the polypeptide rather than the oligosaccharide component. ... 

Scheidereit C, Geisse S, Westphal HM, Beato M (1983) The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus. Nature (London) 304 749-752... 

Williams GT, Morimoto RI (1990) Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment. Mol Cell Biol 10 3125-3136 Willmann T, Beato M (1986) Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA. Nature 324 688-691 Winkler H, Adam G, Mattes E, Schanz M, Hartig A, Ruis H (1988) Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins a binding site for the HAP-1 (CYPl) protein in the UAS region of the yeast catalase T gene. EMBO J 7 1799-1804... 

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