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Heterocyclic compounds, and

Cyclic compounds that contain at least one atom other than carbon within their ring are called heterocyclic compounds, and those that possess aromatic stability are called het erocyclic aromatic compounds Some representative heterocyclic aromatic compounds are pyridine pyrrole furan and thiophene The structures and the lUPAC numbering system used m naming their derivatives are shown In their stability and chemical behav lor all these compounds resemble benzene more than they resemble alkenes... [Pg.460]

This index contains over 40,000 individual entries to the 6200 text pages of Volumes 1-7. The index mainly covers general classes of heterocyclic compound and specific heterocyclic compounds, but also included are natural products, other organic and organometallic compounds where their synthesis or use involves heterocyclic compounds, types of reaction, named reactions, spectroscopic techniques and topics involving heterocyclic compounds. [Pg.507]

Other compounds containing Al-N or Ga-N bonds, including heterocyclic compounds and cluster organometallic compounds, are considered in section 7.3.6. [Pg.256]

A.4 Reactions with heterocyclic compounds and formation of heterocycles... [Pg.403]

Hantzsch 2 gave the name pseudo bases to those carbinols that gave salts with acids by the elimination of water and a simultaneous change of constitution. Such carbinols are common among the nitrogen heterocyclic compounds and the naturally occurring alkaloids e.g., berberine, sanguinarine, chelerythrine. [Pg.167]

The mass spectra of a number of pyridopyrimidines have been determined in these laboratories. Pyridopyrimidin-4(3//)-ones showed features in their spectra common to the fragmentation patterns of other heterocyclic compounds " and more particularly... [Pg.187]

In this review an attempt is made to discuss all the important interactions of highly reactive divalent carbon derivatives (carbenes, methylenes) and heterocyclic compounds and the accompanying molecular rearrangements. The most widely studied reactions have been those of dihalocarbenes, particularly dichlorocarbene, and the a-ketocarbenes obtained by photolytic or copper-catalyzed decomposition of diazo compounds such as diazoacetic ester or diazoacetone. The reactions of diazomethane with heterocyclic compounds have already been reviewed in this series. ... [Pg.57]

V. Synthetic Studies towai d Novel Heterocyclic Compounds and Natural Pi oducts.. 138... [Pg.102]

Applications of our results in 1-hydroxyindole chemistry and our tungstate method to the syntheses of novel heterocyclic compounds and biologically active natural products are summarized in this section. [Pg.138]

The reactions to be discussed may be represented by Eq. (1), where heterocyclic-H is an aromatic heterocyclic compound and R- is a free radical. The reaction is a substitution in that R replaces H, but... [Pg.131]

Quinoxalines undergo facile addition reactions with nucleophilic reagents. The reaction of quinoxaline with allylmagnesium bromide gives, after hydrolysis of the initial adduct, 86% of 2,3-diallyl-l,2,3,4-tetrahydroquinoxaline. Quinoxaline is more reactive to this nucleophile than related aza-heterocyclic compounds, and the observed order of reactivity is pyridine < quinoline isoquinoline < phenan-thridine acridine < quinoxaline. ... [Pg.213]

Cormier and Dure (1963) found another type of luciferin and called it protein-free luciferin. Protein-free luciferin was found in the vapor condensate of freeze-drying whole animals, and also in the 3 5-56 % ammonium sulfate fraction of the crude extract noted above. The protein-free luciferin behaved like an aromatic or heterocyclic compound and it was strongly adsorbed onto Sephadex and other chromatography media, requiring a considerable amount of solvent to elute it. The luminescence reaction of protein-free luciferin in the presence of luciferase required a 500-times higher concentration of H2O2 compared with the standard luciferin preparation. Both types of the luciferin preparation had a strong odor of iodoform. [Pg.316]

Despite the relative simplicity of the kinetics of molecular chlorination, there has so far been only one measurement of the rate coefficient with a heterocyclic compound and the need for more work in this area is indicated. Marino265 found that chlorination of thiophene by chlorine in acetic acid at 25 °C gave the second-order rate coefficient of 10.0 1.5, so that thiophene is 1.7 x 109 times as reactive as benzene in this reaction and this large rate spread is clearly consistent with the neutral and hence relatively unreactive electrophile. [Pg.106]

The wide variation in the entropy factors for both the substituted phenyl and heterocyclic compounds and in particular for the methoxyphenyl and furan derivatives was considered to be strong evidence for solvent effects being predominant in determining the activation entropy. Consequently, discussion of the substituent effects in terms of electronic factors alone requires caution in this reaction. Caution is also needed since rates for the substituted phenyl compounds were only determined over a 20 °C range. The significance of entropy factors has also been indicated by the poor correlation of the data of the electrophilic reactivities of the heterocyclic compounds, as derived from protodemercuration, with the data for other electrophilic substitutions and related reactions572. [Pg.287]

Dihydro-1-vinylnaphthalene (67) as well as 3,4-dihydro-2-vinylnaphtha-lene (68) are more reactive than the corresponding aromatic dienes. Therefore they may also undergo cycloaddition reactions with low reactive dienophiles, thus showing a wider range of applications in organic synthesis. The cycloadditions of dienes 67 and 68 and of the 6-methoxy-2,4-dihydro-1-vinylnaphthalene 69 have been used extensively in the synthesis of steroids, heterocyclic compounds and polycyclic aromatic compounds. Some of the reactions of dienes 67-69 are summarized in Schemes 2.24, 2.25 and 2.26. In order to synthesize indeno[c]phenanthrenones, the cycloaddition of diene 67 with 3-bromoindan-l-one, which is a precursor of inden-l-one, was studied. Bromoindanone was prepared by treating commercially available indanone with NBS [64]. [Pg.53]

Comprehensive Organic Chemistry , Pergamon, Elmsford, NY, 1979, is a six-volume treatise on the synthesis and reactions of organic compounds. The first three volumes cover the various functional groups, vol. 4, heterocyclic compounds, and vol. 5, biological compounds such as proteins, carbohydrates, and lipids. Probably the most useful volume is vol. 6, which contains formula, subject, and author indexes, as well as indexes of reactions and... [Pg.1623]

Stephan I, B Tshisuaka, S Fetzer, F Lingens (1996) Quinaldine 4-oxidase from Arthrobacter sp. Ru61a, a versatile procaryotic molybdenum-containing hydroxylase active towards N-containing heterocyclic compounds and aromatic aldehydes. Eur J Biochem 236 155-162. [Pg.145]

QikProp does not perform MD simulahons but calculates required parameters from supplied 3D structures of molecules. For example, it computes atomic charges using the semi-empirical CM Ip method, ASA is calculated using a 1.4 A probe radius [43]. The recent parameters of QikProp were optimized using 500 drugs and related heterocyclic compounds and the model calculated an of 0.93 and an RMSE of 0.49 for more than 400 drug-like compounds [42]. [Pg.390]

In Chapter 10 of Part A, the mechanistic classification of 1,3-dipolar cycloadditions as concerted cycloadditions was developed. Dipolar cycloaddition reactions are useful both for syntheses of heterocyclic compounds and for carbon-carbon bond formation. Table 6.2 lists some of the types of molecules that are capable of dipolar cycloaddition. These molecules, which are called 1,3-dipoles, have it electron systems that are isoelectronic with allyl or propargyl anions, consisting of two filled and one empty orbital. Each molecule has at least one charge-separated resonance structure with opposite charges in a 1,3-relationship, and it is this structural feature that leads to the name 1,3-dipolar cycloadditions for this class of reactions.136... [Pg.526]

As for H NMR spectroscopy, the same applies for 13C NMR spectroscopy, in that this is now routinely carried out for most organic heterocyclic compounds and as such, the primary literature should be consulted for the examples outlined later in this chapter. [Pg.715]

Hetero Diels-Alder reactions are very useful for constructing heterocyclic compounds, and many important chiral molecules have thus been synthesized. Although the retro Diels-Alder reaction does not itself involve the asymmetric formation of chiral centers, this reaction can still be used as an important tool in organic synthesis, especially in the synthesis of some thermodynamically less stable compounds. The temporarily formed Diels-Alder adduct can be considered as a protected active olefin moiety. Cyclopentadiene dimer was initially used, but it proved difficult to carry out the pyrrolytic process. Pentamethyl cyclopentadiene was then used, and it was found that a retro Diels-Alder reaction could easily be carried out under mild conditions. [Pg.322]

Many large band-gap organic materials have been explored for blue emission. To summarize, they are the distyrylarylene series, anthracenes, perylenes, fluorenes, heterocyclic compounds, and metal complexes. [Pg.350]

The synthesis and chemistry of compounds where germanium is linked to a group 16 element has undergone a number of developments since the field was last surveyed,1 and a review on the subject has been published.162 New developments include the formation of new heterocyclic compounds and formation of multiple bonds to the heavier group 16 elements. A review has also appeared on this subject.163... [Pg.738]

Sawicki, E., S. P. McPherson, T. W. Stanley, J. Meeker, and W. C. Elbert. Quantitative composition of the urban atmosphere in terms of polynuclear aza heterocyclic compounds and aliphatic and polynuclear aromatic hydrocarbons. Int. J. Air Water Pollut. 9 515-524, 1%5. [Pg.122]

The aza-Wittig reaction offers several strategies for the syntheses of heterocyclic compounds, and in Section VI a broad choice of examples is presented. Aza-Wittig reactions can be divided into an intramolecular and an intermolecular variant, the former starting with a molecule 49 (Scheme 26) that contains both an iminophosphorane group and a carbonyl function in a geometrically favorable orientation. [Pg.177]

These imidazoisoindoles were novel heterocyclic compounds and this, together with the associated biological activity,... [Pg.31]

Later Grubbs discovered ruthenium carbene complex and used it for a metathesis reaction to synthesize cyclic compounds 5a-d [Eqs. (6.4) and (6.5)]. In 1995, Grubbs found that ruthenium benzylidene carbene complex Ic," which is now commercially available, has the same reactivity as that of lb. Many researchers have therefore used this complex for olefin metathesis, and this reaction has been useful for the synthesis of carbo- and heterocyclic compounds and fused bicyclic compounds [Eq. [6.6)] °... [Pg.155]

The final chapter in this volume covers the use of sulfur monochloride in the synthesis of heterocyclic compounds and is by O.A. Rakitin and L.S. Konstantinova (Zelinsky Institute, Moscow, Russia). It includes a survey of the extensive work carried out by these authors and other friends and associates of the late Charles Rees on heterocycles containing heterocycles with up to five sulfur atoms and often many nitrogen atoms. In addition, the chapter also shows how sulfur monochloride may be used advantageously in the synthesis of other sulfur heterocycles. [Pg.251]

The enamine adducts formed in the reaction of aromatic amines with DMAD have been found to undergo cyclization leading to heterocyclic compounds, and the mode of these reactions is to a considerable extent influenced by the reaction conditions, the catalyst employed, and also the nature of the functional groups present in the starting amine. The reaction of aniline with methyl propiolate in presence of cuprous acetate, for example, is reported to give a mixture of 2(lH)-quinolone (1) and 4(l//)-quinolone (2) [Eq. (1)]." On the other hand, dimethyl anilinofumarate (3), formed from aniline with DMAD, undergoes... [Pg.281]

This is a rather substantial area of chemistry of the six-membered heterocyclic compounds and one in which, while a few general trends are discernible, there is also an enormous diversity of behaviour depending on the ring system. Consequently, there can be no detailed discussion in this chapter, and the reader is referred to the monograph chapters for information on individual ring systems. [Pg.31]

Hiickel s rule (1931) for planar species states that if the number of ir electrons is equal to 2 + 4n, where n equals zero or a whole number, the species is aromatic. The rule was first applied to carbon-containing monocyclics in which each C is capable of being 5p -hybridized to provide a p orbital for extended v bonding it has been extended to unsaturated heterocyclic compounds and fused-ring compounds. Note that benzene corresponds to n = 1. [Pg.202]


See other pages where Heterocyclic compounds, and is mentioned: [Pg.577]    [Pg.643]    [Pg.646]    [Pg.844]    [Pg.565]    [Pg.16]    [Pg.95]    [Pg.566]    [Pg.605]    [Pg.196]    [Pg.411]    [Pg.144]    [Pg.131]    [Pg.178]    [Pg.143]   


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