Hematology studies

Rare cases of hemolytic anemia, including fatalities, have been reported with the administration of the cephalosporins. The patient should be monitored for anemia If a patient experiences anemia within 2 to 3 weeks after the start of cephalosporin therapy, drug-induced anemia should be considered. If hemolytic anemia is suspected, the primary health care provider will discontinue the drug therapy. The patient may require blood transfusions to correct tire anemia. Frequent hematological studies may be required. 

Albert, L.A. and F. Badillo. 1991. Environmental lead in Mexico. Rev. Environ. Contam. Toxicol. 117 1-49. Anders, E., D.D. Dietz, C.R. Bagnell, Jr., J. Gaynor, M.R. Krigman, D.W. Ross, J.D. Leander, and R Mushak. 1982. Morphological, pharmacokinetic, and hematological studies of lead-exposed pigeons. Environ. Res. 28 344-363. 

Cyclo(Ser-Tyr) exhibited significant activity in the hematological studies, where it increased the rate of calcium induced-coagulation, and decreased the rate of streptokinase-induced fibrinolysis. ... 

Monitoring Because rifabutin may be associated with neutropenia, and, more rarely, thrombocytopenia, consider obtaining hematologic studies periodically in patients receiving prophylaxis. 

Contraindications to procainamide are similar to those for quinidine. Because of its effects on A-V nodal and His-Purkinje conduction, procainamide should be administered with caution to patients with second-degree A-V block and bundle branch block. Procainamide should not be administered to patients who have shown procaine or procainamide hypersensitivity and should be used with caution in patients with bronchial asthma. Prolonged administration should be accompanied by hematological studies, since agranulocytosis may occur. 

P. J. Swart, E. Beljaars, A. Pasma, C. Smit, H. Schuitemaker, and D. K. F. Meijer, Comparative pharmacokinetic, immunologic and hematologic studies on the anti-HIV-1/2 compounds aconitylated and succinylated HSA, J. Drug Target 4 109-116 (1996). 

Hematologic Studies Hematologic study includes estimations of hemoglobin content, packed-cell volume, total erythrocytes, total leukocytes, platelets, or other measures of clotting potential. These should be performed on blood samples collected from all nonrodents, from 10 rats of both genders, from all groups at 3 months, 6 months, thereafter at approximately 6-month intervals, and at termination. If possible, these collections should be from the same rats of each interval. In additions, a pretest sample should be collected from nonrodents. 

Tarantal AF, O Brien WD, Hendrickx AG. Evaluation of the bioeffects of prenatal ultrasound exposure in the cynomolgus macaque (Macaca fascicularis) III. Developmental and hematologic studies. Teratology 1993 47(2) 159-70. 

The ability to produce globulins and cellular proteins can be noted in the hematological studies. 

Detailed hematological studies of several hundred obligatory adult heterozygotes for a-thalassemia suggest that this condition is often associated with a normal blood picture (P23). The hemoglobin concentration varies between 10 and 13 g/100 ml with MCV values of 60-80 and MCH of 22-30 pg per cell hypochromia is not prominent and reticulocytosis is hardly observed. Osmotic fragility of red cells is usually reduced. 

Davis JW, Libke KG. 1968. Hematologic studies in pigs fed clay pigeon targets. JAVMA 152 382-384. 

It is the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukaemia treated by the intramuscular injection of a synthetic compound, 4-aminopteroylglu-tamic acid (aminopterin). This substance is an antagonist of folic acid regarding growth of Streptococcus faecalis R. ... 

The proposed guidelines indicate that, in addition to routine examinations and observations for obvious toxicity and behavioral changes, clinical laboratory tests should be performed at intervals of 3,6,12,18, and 24 months. These tests include hematological studies, blood chemistries, urinanalyses, and residue analyses of tissues. At the completion of the study complete necroscopies are to be performed on all animals. 

Mr. Veere s malnourished state was reflected in his admission laboratory profile. The results of hematologic studies were consistent with an iron deficiency anemia complicated by low levels of folic acid and vitamin Bi2, two vitamins that can affect the development of normal red blood cells. His low serum albumin level was caused by insufficient protein intake and a shortage of essential amino acids, which result in a reduced ability to synthesize body proteins. The psychiatrist requested a consultation with a hospital dietician to evaluate the extent of Mr. Veere s marasmus (malnutrition caused by a deficiency of both protein and total calories) as well as his vitamin and mineral deficiencies. 

In mice orally administered 100 mg/kg of an ethanol extract of cinnamon daily for 90 days, no signs of mortality were observed. Hematological studies indicated a reduction in hemoglobin levels. Increases in reproductive organ weights, sperm motility, and sperm count were observed with no spermatotoxic effects (Shah et al. 1998). 

Hematology Study of blood cell formation (hematopoiesis), the organs that form blood cells, and diseases of the blood. 

At present, the treatment of neuropsychiatric disorders by vitamin B12 supplementation is based mainly on hematological studies. 

It is important that angiographic evaluation is not delayed, since patients who have experienced significant blood are at risk of becoming coagulopathic. It is vital, therefore, to have a variety of blood products available, and coagulation/hematologic studies should be performed before, during, and after the resuscitation phase. 

Figure 9 shows that as with monkeys, men made more interferon in response to a given dose of poly(ICLC) than did women. Hematologic studies in M.S. patients showed acute changes in total wbc, as well as in lymphocytes and granulocytes. Within 4 hours after injection, total wbc increased. As with the monkeys at the higher dose, there was a marked decrease in lymphocytes and an increase in polymorphonuclear leukocytes. Figure 10 shows a typical reaction. 

The acute toxic and pathogenic effects of in rats include pronounced effects on many of the rapidly proliferating normal tissues (l.e., in the intestines, the marrow, and the renal tubules). 184,185 Hematologic studies show a decrease in circulating reticulocytes and lymphocytes after administration of 2, and histologic studies showed striking changes in thymus and spleen.186 Deafness was noted in preclinic trials. 

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