White Hellebore

Two unnamed alkaloids have also been deseribed. One was obtained by Bredemann in work on the alkaloids of white hellebore it occurred in the mother liquors from protoveratrine crystallisation and formed spherical aggregates of needles, m.p. 239-241°. The other was isolated by. Jacobs and Craig during a chromatographic analysis of residual, benzene-soluble alkaloids of green hellebore. It is represented by the formula C27H41 (39)04N, crystallises in six-sided platelets or flat needles, sinters about 130°, effervesces at 170-5°, and on further heating solidifies and finally melts at 272-4° it has [a]n ° — 78° (MeOH). 

Sabadilla Seeds. Processes for the isolation of the total alkaloids and separation of the components have been published by Wright and Luff, by Bosetti and by G. Merck. The more modem methods used by Poethke, Saito, Seiferle et al., Jacobs and Craig, and others for the alkaloids of white and green hellebores (see below) could no doubt also be used to advantage for sabadilla seed. A test for galenical preparations of sabadilla has been devised by Ramstad depending on the presence of chelidonie acid in the seed. ... 

Germano-. germanous, germanium(II). -sulfid, n. germanous sulfide, germanium(II) sulfide. Germer, m. white hellebore (Veratrum). 

Eratz-kupfer, n. copper from waste, -messing, n. brass cuttings, -wurzel, /. white hellebore (root). 

Resveratrol has a long history. It was initially isolated from the roots of white hellebore in 1940. No one paid much attention. In 1963, it was isolated from a plant used for centuries in traditional Japanese and Chinese medicine. Again, this did not attract much attention. The story got a lot hotter in 1992 when the presence of resveratrol in red wine was suggested to be associated with the cardioprotective effects of red wine. 

Hellebore root has been the psychopharmaceutical agent par excellence at various times. It is a plant of the Ranunculaceae family, the roots of which, as we now know, contain several glycosides, some of them rather toxic. White hellebore was traditionally used as an emetic (Vomitivum) and black hellebore as a laxative (Purgativum) in both cases the guiding principle was that a mental illness has a physical cause that can be treated by physical effects,... 

Hellebore found a very wide range of uses mania, melancholy, inflammation of the brain and mental retardation were included among the indications just as much as epilepsy, hydrophobia, violent temper and crazy ideas (Wittem, 1983. p. 14). White and black hellebore could be combined and there is no difficulty in believing the ancient authors when they state that the simultaneous emetic and laxative treatment has a good calming effect The use of hellebore declined in the nineteenth century because the product is difficult to dose and can induce seizures in higher doses. 

The steroidal alkaloids have a nucleus based on 21, 24, or 27 carbon atoms (Fig. 44). The C21 alkaloids are pregnane-derived with nitrogen inserted at C-3, at C-20, or at both positions. They are characteristic of the Apocynaceae Funtumia and Holarrhena species) and the Buxaceae Buxus species). The Buxaceae also produces C24 alkaloids based on the cycloartane skeleton. The most interesting alkaloids are those in the Solanaceae and the Liliaceae. These are C27 alkaloids, and examples include solasodine and solanidine many derivatives are glycosylated. The alkaloids from the Liliaceae, such as veratramine of the white hellebore (Veratrum album), were formerly used for cardiac... 

The rhizome and root of Veratmm album (white hellebore) and the rhizome of Veratrum viride (green hellebore) contain many alkaloids, including hypotensive ester alkaloids and jervine. Veratrum califomicum contains the alkaloids cyclopamine, cycloposine, and jervine. 

Gamier R, Carlier P, Hoffelt J, Savidan A. Intoxication aigue ahmentaire par I eUebore blanc (Veratum album L.). Donnees chniques et analytiques. A propos de 5 cas. [Acute dietary poisoning by white hellebore (Veratrum album L.). Chnical and analytical data. A propos of 5 cases.] Ann Med Interne (Paris) 1985 136(2) 125-8. 

Hellebores flower in winter and early spring, earning names such as Christmas rose i Helleborus niger) or Lenten rose (H. orientalis). Most have green, creamy white, or dull purple blooms, carried over low evergreen foliage. 

Veratrum album. White hellebore. Veratrum album. W. IV. 895. Radix. The root. 

In the same manner the ointment may be prepared of the white hellebore. -, . ... 

Hellebore black Helleborus niger, white H. foetidus, green H. viridus... 

Green more potent than black and white Hellebore. 

Resveratrol (82) is a polyphenolic antioxidant found in many plants, including grapes, nuts, and berries. First isolated in 1940 from the roots of white hellebore Veratrum grandiflorum), it has gained prominence through its association with the highly publicized French Paradox linked to the drinking of red wine. There is an extensive literature on the multiple health benefits attributed to resveratrol and interested readers are referred to several recent reviews that summarize the available data. ... 

Hellebore The dried rhizome and roots of any medicinal herb of the genus Helteborus. especially white hellebore, containing a number of alkaloids, as veretrlne, etc., which acts as a sedative end e depressant. Used ex-temally as a oarasiticids and Insecticide pokeroot pokeweed. 

Veratxine, or Veratria. The alkaloid principle of cevadilla seeds, and of white hellebore. When pure it is a white powder but as usually met with, the powder la yellowish or greeuish-white, insoluble in water. 

Lotion for Man e. Corrosive sublimate, i ounce spirits ol salt (muriatio acid), k ounce water, 1 quart. Or Corrosive subltmiite, 1 drachm sal-ammoniac, f ounce water, 1 pint Or To the last atld strollir decoction of white hellebore, k pint. Used" for mange in horses, cattle, and nogs, when sulphur ointment foils,... 

Veratrum califomicum, commonly loiown as false hellebore or com lily, is a coarse, weedy plant that thrives between 6500-7000 feet of elevation and is avoided by most livestock, but not sheep [28]. The numerous erect stems of the plant are connected to each other by underground stems or rhizomes. Some of the stems bear open clusters (panicles) of dull greenish-white flowers. Fig. (3), whereas others end in a somewhat smaller leaf. The latter. Fig. (4), are a fascinating botanical curiosity. Each leaf blade is supported by a sheath that encircles the... 

OCN American white hellebore false hellebore Indian poke... 

Jervlne a jeveratrum type of Veratrum alkaloid with a C-nor-D-homo structure. M, 425.62, m.p. 238 °C, [a]o -147°. J. is the main alkaloid of white and green hellebore (Veratrum album and V. viride). 

---