Green hellebore

Two unnamed alkaloids have also been deseribed. One was obtained by Bredemann in work on the alkaloids of white hellebore it occurred in the mother liquors from protoveratrine crystallisation and formed spherical aggregates of needles, m.p. 239-241°. The other was isolated by. Jacobs and Craig during a chromatographic analysis of residual, benzene-soluble alkaloids of green hellebore. It is represented by the formula C27H41 (39)04N, crystallises in six-sided platelets or flat needles, sinters about 130°, effervesces at 170-5°, and on further heating solidifies and finally melts at 272-4° it has [a]n ° — 78° (MeOH). 

Sabadilla Seeds. Processes for the isolation of the total alkaloids and separation of the components have been published by Wright and Luff, by Bosetti and by G. Merck. The more modem methods used by Poethke, Saito, Seiferle et al., Jacobs and Craig, and others for the alkaloids of white and green hellebores (see below) could no doubt also be used to advantage for sabadilla seed. A test for galenical preparations of sabadilla has been devised by Ramstad depending on the presence of chelidonie acid in the seed. ... 

The rhizome and root of Veratmm album (white hellebore) and the rhizome of Veratrum viride (green hellebore) contain many alkaloids, including hypotensive ester alkaloids and jervine. Veratrum califomicum contains the alkaloids cyclopamine, cycloposine, and jervine. 

Take of Green hellebore bruised, eight ounces. Diluted alcohol, two pints and a half... 

Veratrum viride. American hellebore green hellebore American veratrum Indian poke. Dried rhizome and roots of Veratrum viride Ait., Liliaceae. Habit. North America. Constit. The alkaloids jervine, pseudojervine, rubijervine, cevadine, germitrine. germidine, veratralbine, veratroidine. See Seiferle et ai.. J. Econ. E-stomol 35, 35 (1942) Fried el al. J. Am. Chem. Soc. 72, 4621 (1950). Review Kupchan, J. Pharm Sci 50, 273-287 (]961). 

Jervlne a jeveratrum type of Veratrum alkaloid with a C-nor-D-homo structure. M, 425.62, m.p. 238 °C, [a]o -147°. J. is the main alkaloid of white and green hellebore (Veratrum album and V. viride). 

The Yeratrum genus (Liliaceae) is also rich in steroidal alkaloids. They are derived from the white hellebore Yeratrum album) and the green hellebore Y. viridis). These alkaloids have steroid skeletons though some are highly oxygenated—the protoveratrines A and B contain up to nine oxygen atoms. 

Green Hellebore. Jervine, C27H39OJN rubijervine, C27H43O2N pseudcjervine, p l otoveratridine, C32H54O9N germine, ... 

Hellebores flower in winter and early spring, earning names such as Christmas rose i Helleborus niger) or Lenten rose (H. orientalis). Most have green, creamy white, or dull purple blooms, carried over low evergreen foliage. 

Hellebore black Helleborus niger, white H. foetidus, green H. viridus... 

Green more potent than black and white Hellebore. 

---