Helicobacter gastric cancer

Correa, P. and Ruiz, B. (1992). Helicobacter pylori and gastric cancer. In Helicobacter pylori and Gastroduodenal disease (eds. B.J. Rathbone and R.V. Heatley) pp. 158-164. Black-well Scientific Publications, Oxford. 

Helicobacter pylori 1.66/1578 (68) Peptic ulcer, gastric cancer, gastric lymphoma (MALT)... 

Uemura N, Okamoto S, Yamamoto S, M atsu-mura N, Yamaguchi S, Yamakido M, Tan iya-ma K, Sasaki N, Schlemper RJ Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001 345 784-789. 

Helicobacter pylori infections are now also accepted as the primary cause of peptic ulcer disease (PUD). In the US, approximately four to five million people suffer from PUD, and the economic consequences of the disease are responsible for as much as 3 to 4 billion in annual health care costs. The situation is even more serious in many developing countries, where HP infections, PUD and gastric cancer are major causes of morbidity. 

Helicobacter infections are of great concern worldwide due to its association with peptic ulcer disease and gastric cancer. Resistance to available antimicrobials is on the rise, not only in the US but also in the developing countries. This increase in resistance has opened the door for research into... 

Goodwin CS. (1997) Helicobacter pylori gastritis, peptic ulcer, and gastric cancer Clinical and molecular aspects. Clin Infect Dis 25 1017-1019. 

Maeda, S., Otsuka, M., Hirata, Y, Mitsuno, Y, Yoshida, H., Shiratori, Y, Masuho, Y, Muramatsu, M.A., Seki, N., and Omata, M., cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells, Biochem. Biophys. Res. Commun., 284, 443-449, 2001. 

Answer Peptic ulcer disease is most frequently secondary to either Helicobacter pylori infection or use of NSAIDs. The patient does admit to NSAID use (naproxen), but should also be checked for concomitant H. pylori infection at time of endoscopy or by a serology test. If the patient was found to have H. pylori, an appropriate eradication regimen should be prescribed. The patient should also be counseled to avoid NSAIDs. The patient should be prescribed a proton pump inhibitor for 8 weeks to heal the ulcer. A repeat endoscopy should be done at that time to document ulcer healing and rule out gastric cancer. In addition, the patient should be counseled to stop smoking, which is a risk factor for more severe peptic ulcer disease. 

Axinellamines, e.g. axinellamine B (109), from the Australian marine sponge Axinella sp. with a unique heterocyclic skeleton have bactericidal activity against Helicobacter pylori, the bacterium associated with pepticular and gastric cancer, at 1 mM [88]. 

Heneghan, M.A., McCarthy, C.F., Janulaityte, D., Moran, A.P. Relationship of anti-Lewis x and anti-Lewis y antibodies in serum samples from gastric cancer and chronic gastritis patients to Helicobacter py/on -mcdiated autoimmunity. Infect Immun 69 (2001) 4774 1781. 

Four imidazo-azolo-imidazole alkaloids, axinellamines A-D (87-90), vere isolated from an Australian Axindla sp. compounds 88-90 had bactericidal activity against Helicobacter pylori, a Gram-negative bacterium associated with pepticular and gastric cancer [125]. 

Feiz HR and Mobarhan S (2002) Does vitamin C intake slow the progression of gastric cancer in Helicobacter py/on-infected populations Nutrition Reviews 60,34-6. 

The EUROGAST Study Group. An international association between Helicobacter pylori infection and gastric cancer. Lancet 1993 341 1359-62. 

FIGURE 33-2. The natural history of Helicobacter pylori infection in the pathogenesis of gastric ulcer and duodenal ulcer, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. 

Abstract Persistent colonization of the human stomach by Helicobacter pylori is a risk factor for the development of peptic ulcer disease and gastric cancer. Adhesion of microbes to the target tissue is an important determinant for successful initiation, establishment and maintenance of infection, and a variety of different candidate carbohydrate receptors for H. pylori have been identified. Here the different the binding specifities, and their potential role in adhesion to human gastric epithelium are described. Finally, recent findings on the roles of sialic acid binding SabA adhesin in interactions with human neutrophils and erythrocytes are discussed. 

Asaka, M., Takeda, H., Sugiyama, T., and Kato, M. (1997) What role does helicobacter pylori play in gastric cancer Gastroenterology, 113, S56-S60. 

G. and Figura, N. 2000, Antibody response to Helicobacter pylori CagA and heat-shock proteins in determining the risk of gastric cancer development. Dig.Liver Dis., 32 378-383... 

Opazo, P., Muller, L, Rollan, A., Valenzuela, P., Yudelevich, A., Garcia-de, 1. G., Urra, S. and Venegas, A. 1999, Serological response to Helicobacter pylori recombinant antigens in Chilean infected patients with duodenal ulcer, non-ulcer dyspepsia and gastric cancer. PMB, 107 1069-1078... 

Breath analysis was also used to detect the presence of Helicobacter pylori, which has been implicated as a major cause of gastritis, peptic ulcer, and gastric cancer... 

Huang, J., Sridhar, S., Chen, Y., and Hunt, R., Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology, 114,1169-1179,1998. 

---