Cell differentiation antigens

Cellular therapies in transplantation and cancer are based on specific cells separated or sorted from human blood, bone marrow, or cord blood by means of their specific cell surface markers or cell differentiation antigens, e.g., CD3, CD4, CD8, CD 14, CD 19, and CD34. For example, the CD34+ stem cells, especially those derived from human embryos, have the capacity to differentiate in culture to generate different somatic cells, e.g., liver cells, heart cells, neurons, etc. This exploding field of research is now termed regenerative medicine. 

Cell differentiation antigens (cluster of differentiation, CD) 187,407 Cell membranes 3... 

C23. Cobbold, S., Hale, G., and Waldmann, H., Non-lineage, LFA-1 family, and leucocyte common antigens New and previously defined clusters. In Leukocyte Typing III White Cell Differentiation Antigens (A. J. McMichael, P. C. L. Beverley, S. Cobbolds, etal., eds.), pp. 788-804. Oxford University Press, Oxford, 1987. 

Zl. Zhou, L.-J., and Tedder, T. F., CD20 workshop panel report. In Leukocyte Typing V White Cell Differentiation Antigens (S. F. Schlossman, L. Boumsell, W. R. Gilks, et al. eds.), pp. 511-514. Oxford University Press, New York, 1995. 

Leucocyte Typing VI, et al. White Cell Differentiation Antigens. In Kishimoto T, Goyert S, Kikutani H, eds. Sixth International Workshop and Conference 1997. Kobe, Japan Garland Publishers 1997. 

Inadequate performance may result from lack of antigen specificity, e.g., tumor-specific antigens are often differentiation antigens which also occur, although in a lower density on nontarget cells (Poste, 1984). 

B cells also have impact on T-cell differentiation. B-cell antigen presentation plays an important role at promoting Th2 responses and pathophysiology during allergic disorders. It has been shown that B-cell -/- mice and in mice selectively deficient in MHCII on B cells had decreased Th2 cytokines IL-4 and IL-5 [152]. Also in another study it has been reported that B-cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce Th2 cytokines IL-5 and IL-13 [42]. 

Basophils Drive Th2-Cell Differentiation through Secretion ofTh2 Cytokines and Antigen Presentation... 

Petti M.A., Matheson S.F. and Burd G.D. (1999). Differential antigen expression during metamorphosis in the tripartite olfactory system of the African clawed frog, Xenopus laevis. Cell Tiss Res 297, 383-396. 

The differentiation effect of lycopene was associated with elevated expression of several differentiation-related proteins, such as cell surface antigen (CD14), oxygen burst oxidase and chemotactic peptide receptors (Amir et al., 1999). Recently, it has also been reported that lycopene was also able to stimulate the differentiation marker alkaline phosphatase activity in... 

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