Health and Environmental Sciences Institute

International Life Sciences Institute (ILSI), Health and Environmental Sciences Institute (HESI)... 

Farmer P Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment ILSl/HESl research programme on alternative cancer models results of Syrian hamster embryo cell transformation assay. International Life Sciences Institute/Health and Environmental Science Institute. Toxicol Pathol 2002 30 536-8. 

Smith LL, Brent RL, Cohen SM, Doerrer NG, Goodman JI, Greim H, Holsapple MP, Lightfoot RM (2008) Predicting future hmnan and environmental health challenges the Health and Environmental Sciences Institute s scientific mapping exercise. Crit Rev Toxicol 38 817-845... 

Richard JuDSON U.S. Environmental Proteetion Agency, Office of Research and Development, Research Triangle Park, NC, USA James H. Km ILSI Health and Environmental Sciences Institute, Washinpjton,... 

One of the early concerns about the application of DNA microarray to toxicology has been how to properly compare experiments that use a wide variety of commercial and proprietary platforms, protocols, and analyses methods. The Health and Environmental Sciences Institute (HESI) of the International Life Sciences Institute (ILSI) has... 

A number of private organizations fund biomonitoring programs for research purposes and to assess exposure at the individual level. The efforts of the American Chemistry Council s Long-Range Research Initiative, the International Life Sciences Institute Health and Environmental Sciences Institute (ILSI-HESI) Biomonitoring Technical Committee, and private laboratories that cater to individual requests to biomonitor for chemicals are highlighted below. 

Syracuse Research Corporation program to predict Henry s law constant Health and Environmental Sciences Institute Hartree-Fock Heat of Formation... 

In 1996 a collaborative effort was subsequently initiated under the auspices of the Health and Environmental Sciences Institute (HESI) branch of the International Life Sciences Institute (ILSI) with the specific purpose of facilitating a focused systematic evaluation of several of the new alternative models proposed within the ICH guidance. Participation in this research collaboration was global in scope encompassing Europe, Japan, and the United States and... 

ILSI (2000). Aggregate Exposure Assessment Model Evaluation and Refinement Workshop Report, International Life Sciences Institute (Health and Environmental Sciences Institute), ILSI Press, Washington, DC, USA. 

Further description of alternative models and their evaluation and validation is given by Blain et al. Validation exercises are taking place at the American National Institute of Environmental Health (NIEH), the International Life Science Institute/Health and Environmental Sciences Institute(ILSI/HESI), the Japanese Central Institute for Experimental Animals/ National Institute of Health Sciences (CIEA/NIHS), and the Dutch Public Institute for Safety and Environment (RIVM). 

Ozolins TRS, Thomson JJ. Use of WEC in pharmaceutical screening/testing. I IP,SI (Health and Environmental Sciences Institute) Workshop on Alternative Assays for Developmental Toxicity Testing [http //www.hesiglobal.org/Coimnittees/TechnicalCommittees/DART/ HESIAltAssayPresentations.htm. Accessed May 1 2009. 

Focal Point in China, and the ILSI Health and Environmental Sciences Institute. ILSI also accomplishes its work through the ILSI Research Foundation (composed of the ILSI Human Nutrition Institute and the ILSI Risk Science Institute) and the ILSI Center for Health Promotion. 

ILSI Health and Environmental Sciences Institute (1996) Replacing the Draize eye irritation test scientific background and research needs. J Toxicol Cutaneous Ocular Toxicol 15 211-234... 

International Life Sciences Instimte (ILSI) (1997). An evaluation of EPA s proposed guidelines for carcmc en risk assessment using chloroform and dichloroacetate as case studies report of an expert panel. ILSI Health and Environmental Sciences Institute, Washington, DC. 

A monse popnlation-based approach may also be employed to inform the mode of action for dmg toxicity. A recent demonstration of this apphcation is a stndy that ntilized a panel of inbred strains to investigate the molecnlar mechanisms of genetic sensitivity to isoniazid-induced steatosis (Church et al., 2014). The study was conducted as a consortia effort by manbers of the Health and Environmental Sciences Institute (HESl) s Apphcation of Genomics to Mechanism-based Risk Assessment Technical Committee. In that study, a combined transcriptontic, metabolomic, and pharmacoge-netic analysis was utilized to provide evidence for a novel hypothesis that isoniazid increases the capacity for formation of lipid droplets while concurrently reducing the capacity for exporting stored fat from the hepatocytes in sensitive strains. 

Berridge, B.R., Pettit, S., Walker, D.B., Jaffe, A.S., Schultze, A.E., Herman, E., Reagan, W.J., Lipshultz, S.E., Apple, F.S., York, M.l. (2009). A translational approach to detecting drug-induced cardiac injury with cardiac troponins consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute. Am. Heart J. 158(l) 21-29. 

Among all of the work in progress at the time, two major collaborative projects were at the center of this review, one under the auspices of the International Life Sciences Institute, Health, and Environmental Sciences Institute (ILSl-HESl), Cardiovascular Safety Subcommittee Initiative with membership from Academia,... 

Bass AS, Darpo B, Breidenbach A, Bruse K, Feldman HS, Games D, Hammond T, Haverkamp W, January C, Koemer J, Lawrence C, Leishman D, Roden D, Valentin JP, Vos MA, Zhou YY, Karluss T, Sager P (2008) International life sciences institute (Health and environmental sciences institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes. Br J Pharmacol 154 1491-1501... 

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