Head and neck tumor

Early clinical studies clearly demonstrated that cisplatin could be administered safely and concurrently with radiation therapy (73-75). Early clinical trials that demonstrated the promise of the combination of cisplatin and radiation therapy included the treatment of brain tumors (76,77), head and neck tumors (78), malignant melanoma (79), and bladder cancer (80). Early clinical trial integrating carboplatin administration with radiation therapy was carried out in patients with locally advanced nonsmall cell lung cancer (NSCLC) (81). A hypothesis put forth by Coughlin and colleagues (81) was that the best clinical outcomes would be achieved with the combination of cisplatin and radiation therapy in tumors that were responsive to cisplatin. 

Hesse K, Heinrich B, Zimmermann F, et al. Combined radiochemotherapy with docetaxel in patients with unresectable locally advanced head and neck tumors. Strahlenther Onkol 2000 176(2) 67—72. 

Riviere, A., Becker, J., and Loning, T. (1991). Comparative investigation of c-erbB2/neu expression in head and neck tumors and mammary cancer. Cancer 67, 2142-2149. 

Eisbruch, A., Blick, M., Lee, J. S., Sacks, P. G., and Gutterman, J. (1987). Analysis of the epidermal growth factor receptor gene in fresh human head and neck tumors. Cancer Res. 47, 3603-3605. 

Dose-limiting toxidty is myelosuppression primarily thromboqrtopenia, although neutropenia was also noted [111]. So far, liposomal lurtotecan has shown limited activity in phase II studies of ovarian, and head and neck tumors [112-114]. 

Nordsmark M, Bentzen SM, Rndat V et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005 77(1) 18-24. 

Bauer FP, Westhofen M. Vestibulotoxische Effekte des zytostatikums Carboplatin bei Patienten mit Kopf-Hals-Tumoren. [Vestibulotoxic effects of the cytostatic drug carboplatin in patients with head and neck tumors.) HNO 1992 40(l) 19-24. 

A peptide (DPI), comprised of a protein transduction domain fused to an antimicrobial peptide (AMP) KLAKLAKKLAKLAK, triggered apoptosis in murine fibrosarcoma (MCA205) and human head and neck tumor cell lines in vitro. It also induced tumor apoptosis and reduction of tumor volume (MCA205) by direct intratumor injection [245]. 

PCR HPV Uterine cervix and some head and neck tumors... 

Eiedler W, Hoppe C, Schimmel B, et al. Molecular characterization of head and neck tumors by analysis of telomerase activity and a panel of microsatellite markers. Int J Mol Med. 2002 9(4) 417-423. 

Namazie A, Alavi S, Olopade OI, et al. Cyclin D1 amplification and pl6(MTSl/CDK4I) deletion correlate with poor prognosis in head and neck tumors. Laryngoscope. 2002 112(3) 472-481. 

Biosynthesis of the appropriate Cer subspecies is apparently very important because head and neck tumors have lower proportions of C,g-Cer than does neighboring normal tissue, and transfection of the CerSl/Lassl gene into head and neck tumor cells in culture suppressed cell growth (S. Koybasi, 2004). 

The tumor imaging agent was designed in Japan in the early eighties [168,169] and used for the detection of medullary thyroid carcinomas and head and neck tumors in patients [170,171]. Planar and SPECT imaging were applied to rapidly assess head... 

Cisplatin, in combination with bleomycin, etoposide, ifosfamide, or vinblastine, cures 90% of patients with testicular cancer. Used with paclitaxel, cisplatin induces complete response in most patients with carcinoma of the ovary. Cisplatin produces responses in cancers of the bladder, head and neck, cervix, and endometrium all forms of carcinoma of the lung anal and rectal carcinomas and neoplasms of childhood. The drug sensitizes cells to radiation therapy and enhances control of locally advanced lung, esophageal, and head and neck tumors when given with irradiation. 

Kuriakose, M. A., Chen, F. A., Egilmez, N. K., Jong, Y. S., Mathiowitz, E., DeLacure, M. D., Hicks, W. L., Jr., Loree, T. L. and Bankert, R. B., Interleukin-12 delivered by biodegradable microspheres promotes the antitumor activity of human peripheral blood lymphocytes in a human head and neck tumor xenograft/SCID mouse model, Head Neck, 22(1), 57, 2000. 

Greish, K., AraM, K., Li, D. et al. (2009) Silk-elastin-like protein polymer hydrogels for localized adenoviral gene therapy of head and neck tumors. Biomacromolecules, 10, 2183-2188. 

Greish, K., Frandsen, J., Scharff, S. et al. (2010) Silk-elastin-Uke protein polymers improve the efficacy of adenovirus thymidine kinase enzyme prodrug therapy of head and neck tumors. Journal of Gene Medicine, 12, 572-579. 

Baum U, Greess H, Fell M, Nomayr A, Lenz M (2000) Imaging of head and neck tumors-methods CT, spiral-CT, multi-slice-spiral-CT. Eur J Radiol 33 153-160... 

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