Hazardous Substance Data Base

HSDB. 1988. Hazardous Substances Data Base - computer printout for bis(chloromethyl) ether. National Library of Medicine, National Toxiology Information Program, Bethesda, MD. 

U.S. Department of Health and Human Services, File Aluminum Phosphide Hazardous Substance Data Base (HSDB), HHS, Washington, DC, 1994. 

Human exposure to HFC-134a occurs via inhalation from accidental leaks of air conditioning units and refrigerators, from spills or industrial use, and from use of metered-dose inhalers such as those that deliver medication for the treatment of asthma (Hazardous Substance Data Base (HSDB) 1998 Alexander and Libretto 1995). 

HSDB. 1988. Hazardous Substance Data Base. Record no. 1667. On-line 08/19/88. ... 

ERA = Environmental Protection Agency HSDB = Hazardous Substance Data Base NCI = National Cancer Institute... 

HSDB (Hazardous Substance Data Base). 1988. Record No. 802. On-line computer database, August 14, 1988. Nation Library of Medicine (NLM). 

Health Effects Assessment Summary Table hypoxanthine-guanine phosphoribosyl transferase hexose monophosphate shunt Hazardous Substances Data Base concentration causing 50% enzyme inhibition International Agency for Research on Cancer Institute for Cancer Research concentration x exposure time incapacitating to 50% of exposed individuals intramuscular intraperitoneal... 

HSDB (1993) Mechlorethamine. Hazardous Substance Data Base, online file, retrieved March 1993. National Library of Medicine, Washington, DC. 

POISINDEX (1993) Mechlorethamine. Micromedex, Inc., retrieved as part of Hazardous Substances Data Base (HSDB), March 1993. 

Other databases supplied by NLM are the Hazardous Substance Data Base (HSDB), the Registry of Toxic Effects of Chemical Substances (RTECS), and the Medical Literature Analysis and Retrieval System (MEDLARS). NLM also supplies other specialized databases called CANCERLIT, DART, GENETOX, IRIS, CCRIS, and CHEMID. 

Sources of information that can be accessed for evaluating products include the Hazardous Substances Data Base, which contains a summary of the fate of the substance in the environment and can be accessed via MEDLARS (Medical Literature Analysis and Retrieval System) [a.405], the EPA AQUIRE (Environmental Protection Agency-Aquatic Life) data base, which contains a listing of aquatic toxicity data for many industrial chemicals [a.406], Syracuse University s data base of fate studies [a.407], and quantitative structure-activity relationships (QSARs) such as the EPA programme ECOSAR (Ecological... 

The following is a synopsis of current scientific toxicity and fate information for the top chemicals (by weight) that facilities within this sector self-reported as released to the environment based upon TRI data. The information contained below is based upon exposure assumptions that have been conducted using standard scientific procedures. The effects listed must be taken in context of these exposure assumptions that are more fully explained within the full chemical profiles in the Hazardous Substances Data Bank (HSDB) and the Integrated Risk Information System (IRIS), both accessed via the Internet. 

The CERCLA Priority List of Hazardous Substances has been annotated with information on the types of wastes and the possible biotechnological treatment methods, as shown in Table 1. The remarks on biotreatabihty of these hazardous substances are based on data from numerous papers, reviews, and books on this topic [4-8]. Databases are available on the biodegradation of hazardous substances. Eor example, the Biodegradative Strain Database [9] (bsd.cme.msu.edu) can be used to select suitable microbial strains for biodegradation applications, while the... 

HAZDAT. 1994. Hazardous Materials Data Base. Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA. 

OHM-TADS Oil and Hazardous Materials - Technical Assistance Data Base DOT/UN/NA/IMCO = Department of Transportation/United Nations/North America/International Maritime Consultive Organization HSDB = Hazardous Substances Data Bank NCI = National Cancer Institute... 

If measured values are not available for the chemical of interest, a substructure search should be conducted to attempt to identify a close structural analog which has a measured value. Several options are available, a few of which allow the rapid identification of an analog with measured values. For example, there are free databases on the internet that are substructure searchable. ChemlDp/us (Table 1) is substructure searchable for all of the >6000 chemicals that are in the Hazardous Substances Data Bank (HSDB) as well as the 269 000 structures that are in the ChemlDp/us file. ChemS (Table 1) can simultaneously substructure search the 20 000 chemicals in the four files of the Environmental Fate Data Base (EFDB) [4,5]. 

The New Jersey Department of Environmental Protection uses the TXDS method of consequence analysis to estimate potentially catastrophic quantities of toxic substances, as required by the New Jersey Toxic Catastrophe Prevention Act (TCPA). An acute toxic concentration (ATC) is defined as the concentration of a gas or vapor of a toxic substance that will result in acute health effects in the affected population and 1 fatality out of 20 or less (5% or more) during a 1-hr exposure. ATC values, as proposed by the New Jersey Department of Environmental Protection, are estimated for 103 extraordinarily hazardous substances and are based on the lowest value of one of the following (1) the lowest reported lethal concentration (LCLO) value for animal test data, (2) the median lethal concentration (LC50) value from animal test data multiplied by 0.1, or (3) the IDLH value. 

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