Hazardous Substance Data Base HSDB

U.S. Department of Health and Human Services, File Aluminum Phosphide Hazardous Substance Data Base (HSDB), HHS, Washington, DC, 1994. 

Human exposure to HFC-134a occurs via inhalation from accidental leaks of air conditioning units and refrigerators, from spills or industrial use, and from use of metered-dose inhalers such as those that deliver medication for the treatment of asthma (Hazardous Substance Data Base (HSDB) 1998 Alexander and Libretto 1995). 

POISINDEX (1993) Mechlorethamine. Micromedex, Inc., retrieved as part of Hazardous Substances Data Base (HSDB), March 1993. 

Other databases supplied by NLM are the Hazardous Substance Data Base (HSDB), the Registry of Toxic Effects of Chemical Substances (RTECS), and the Medical Literature Analysis and Retrieval System (MEDLARS). NLM also supplies other specialized databases called CANCERLIT, DART, GENETOX, IRIS, CCRIS, and CHEMID. 

The following is a synopsis of current scientific toxicity and fate information for the top chemicals (by weight) that facilities within this sector self-reported as released to the environment based upon TRI data. The information contained below is based upon exposure assumptions that have been conducted using standard scientific procedures. The effects listed must be taken in context of these exposure assumptions that are more fully explained within the full chemical profiles in the Hazardous Substances Data Bank (HSDB) and the Integrated Risk Information System (IRIS), both accessed via the Internet. 

HSDB. 1988. Hazardous Substances Data Base - computer printout for bis(chloromethyl) ether. National Library of Medicine, National Toxiology Information Program, Bethesda, MD. 

HSDB. 1988. Hazardous Substance Data Base. Record no. 1667. On-line 08/19/88. ... 

If measured values are not available for the chemical of interest, a substructure search should be conducted to attempt to identify a close structural analog which has a measured value. Several options are available, a few of which allow the rapid identification of an analog with measured values. For example, there are free databases on the internet that are substructure searchable. ChemlDp/us (Table 1) is substructure searchable for all of the >6000 chemicals that are in the Hazardous Substances Data Bank (HSDB) as well as the 269 000 structures that are in the ChemlDp/us file. ChemS (Table 1) can simultaneously substructure search the 20 000 chemicals in the four files of the Environmental Fate Data Base (EFDB) [4,5]. 

ERA = Environmental Protection Agency HSDB = Hazardous Substance Data Base NCI = National Cancer Institute... 

HSDB (Hazardous Substance Data Base). 1988. Record No. 802. On-line computer database, August 14, 1988. Nation Library of Medicine (NLM). 

HSDB (1993) Mechlorethamine. Hazardous Substance Data Base, online file, retrieved March 1993. National Library of Medicine, Washington, DC. 

OHM-TADS Oil and Hazardous Materials - Technical Assistance Data Base DOT/UN/NA/IMCO = Department of Transportation/United Nations/North America/International Maritime Consultive Organization HSDB = Hazardous Substances Data Bank NCI = National Cancer Institute... 

Although we have access to an enormous amount of information, the quality and reproducibility of data varies considerably. Governmental and regulatory influences have not provided any guarantees as to the accuracy of data related to xenobiotics and the researcher needs to understand the purpose and mandates behind an information resource to fully evaluate the data contained within. For example, the National Institute for Occupational Safety and Health (NIOSH) Registry of Toxic Effects of Chemical Substances (RTECS) criteria for selection of data is not based on the reproducibility of that data. Other sources, such as the National Library of Medicine s Hazardous Substances Databank (HSDB), present information compiled from a wide variety of source materials that are extensively reviewed by experts. 

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