Hannoa

Chaparrinone Ailanthus altis.sima, Hannoa klaineana Bitter [antiviral]... 

Simaroubaceae 15 a. Brucea javanica (57-59) 15b. Castela texana 60) 15c. Hannoa klaineana 61) 15d. Simaba multiflora 56, 62) 15e. Soulamea soulameoides (56)... 

Fastre RV, Luyengi L, Vanhaelen M, Declercq JP, Meerssche MV (1987) Two Quassinoids and Two Coumarinolignoids from Hannoa klaineana Roots. Phytochemistry 26 317... 

Quassinoids.—The structure of soulameolide (108), a new C25 quassinoid from Soulamea tomentosa, has been established by X-ray analysis.The search for biologically active compounds continues. Undulatone (109) from Hannoa undulata, 6a-tigloyloxychapparinone (110) from Ailanthus integrifoliaj and 6a-senecioylchapparinone (111) from Simaba multiflora have antileukaemic... 

Hannoa XT, Jamieson G A Activatioa of platelets by alph llwoinbui is a receptor-medialed event J Biol Oiem 261 15928,1986... 

The P-carboline alkaloids harman [1] and pavettine [4] from the bryozoan Costaticella hastata (207) are known from numerous terrestrial plants. Still another bryozoan compound (S)-1-(l -hydroxyethyl)- P-carboline [3] is new but closely related to 1-ethyl-P-carboline [2] present in the bryozoan. It is also known from the roots of Hannoa klaineana (Simaroubaceae) (208) and 1-acetyl-P-carboline [5] from Arenaria kansuensis (Caryophyllaceae) (209). Incidentally, pavettine [4] was detected in only one collection of the bryozoan. 

Hannoa chlorantha Planch, is a shrub used in Angolese traditional medicine, and the last two decades only a quassinoid was isolated of Hannoa chlorantha, 14-hydroxychaparrinone (138) [60],... 

Since then, seven more C25 quassinoids have been discovered Odyendane (215) and odyendene (216) from the Odyendea gabonensis [90], klaineanolide A (217) and B (218) from the Hannoa klaineana [61], indaquassin F (219) from the Quassia indica [80], javanicinoside E (220) isolated from the Picrasma javanica [76] and the new epimer from simarolide (221) [91],... 

Hannoa chlorantha and Hannoa klaineana are used in traditional medicine of Central African countries against fevers and malaria. Four stem bark extracts from H. klaineana and for quassinoids from H. chlorantha were examined in vitro against P. falciparum NF 54 [100],... 

Chaparrinone (226) is a major quassinoid found in the fruits of Hannoa klaineana Pierre and Engler [132]. 

Lumonadio et al. isolated five quassinoids from the root bark of Hannoa klaineana. Of these quassinoids, only 15-desacetyl-undulactone (70) was active against P-388 mouse lymphocytic leukemia cells and colon 38 adenocarcinoma in mice. Undulactone (71) and especially 15-0-"-D-glucopyranosyl-21-hydroxy-glaucarubolone (72) were more toxic, while 6a-tigloyloxy-glaucarubol (73) and 21-hydroxy-glaucarubolone (74) were inactive [27]. 

A mixture of quassinoids from Hannoa undulata (Sima-roubaceae) prevented penetration of tomato roots by infective juveniles of the root-rot nematode, Meloidogyne javanica, at 1-5 xg/ml. The major components of the mixture were chapparrinone (56), klaineanone (59), and glaucaruba-lone (57) (Chitwood, 1992). The primary effect appeared to be on the motility of the nematodes. 

Lumonadio, L. and M. Vanhalen, Indole alkaloids from Hannoa klaineana roots. Phytochemistry, 23, 453-455 (1984). 

Francois G, Diakanamwa C, Timperman G, Bringmann G, Steenackers T, Atassi G, Looveren MV, Holenz J, Tassin JP, Assi LA, Vanhaelen-Fastre R, Vanhaelen M (1998) Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol 28 635-640... 

Wani MC, Taylor HL, Thompson JB, Wall ME, McPhail AT, Onan KD (1979) Plant antitumour agents-XV Isolation and x-ray crystal structure of a new antileukaemic quassinoid undulatone from Hannoa undulate. Tetrahedron 35 17-24... 

Class B quassinoids with the C-8(ll)-oxymethylene bridge reported from Ailanthus and Hannoa. 

Hannoa klaineana Pierre et Engl. Antispasmodic (gastro-intestinal) (R) [132] ... 

Another major indication of the Simaroubaceae also focuses on the respiratoiy system, and Ailanthus altissima, A. excelsa, A. triphysa, Brucea antidysenterica, Hannoa klaineana. Quassia africana, Q. gabonensis, and Q. undulata are prescribed in case of serious pulmonary infections (bronchitis, asthma, cough,... 

Lumonadio L, Atassi G, Vanhaelen M, Vanhaelen-Fastre R (1991) Antitumor activity of quassinoids from Hannoa Idaineana. J Ethnopharmacol 31 59-65... 

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