Costaticella hastata

The manzamine alkaloids are characterized by a complex pentacyclic diamine linked to C-l of a B-carboline moiety. The first B-carboline compound (norharman and harman) was reported from a bioluminiscent marine dino-flagellate Noctiluca miliaris [31], followed by the discovery of the eudistomins from Eudistoma olivaceum [32, 33, 34], Their occurrence has been reported not only from sponges and tunicates, but also from the Bryozoan Costaticella hastata [35], and Cribricellina cribraria [36] and lately from the Cnidaria (Villagorgia rubra) exemplified by the Villagorgins [37]. 

Scheme 17. Hannan [1], 1-ethyl-p-carboline [2], S-l-(l -hydroxyethyl)-P-carboline [3], and pavet-tine [4] from the bryozoan Costaticella hastata. 1-Acetyl-P-carboline [5] are known from Arenaria kansuensis.

The P-carboline alkaloids harman [1] and pavettine [4] from the bryozoan Costaticella hastata (207) are known from numerous terrestrial plants. Still another bryozoan compound (S)-1-(l -hydroxyethyl)- P-carboline [3] is new but closely related to 1-ethyl-P-carboline [2] present in the bryozoan. It is also known from the roots of Hannoa klaineana (Simaroubaceae) (208) and 1-acetyl-P-carboline [5] from Arenaria kansuensis (Caryophyllaceae) (209). Incidentally, pavettine [4] was detected in only one collection of the bryozoan. 

Blackman, A.J., Matthews, D.J., and Narkowicz, C. (1987a) 3-Carboline alkaloids from the marine bryozoan Costaticella hastata. J. Nat. Prod., 50, 494-496. 

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