Quassinoids from Hannoa klaineana

Lumonadio L, Atassi G, Vanhaelen M, Vanhaelen-Fastre R (1994) Antitumor activity of quassinoids from Hannoa klaineana. J Ethnopharmacology 31 5965... 

Lumonadio, L., and M. Vanhaelen Canthin-6-one, Undulatone and two New Quassinoids from Hannoa klaineana Roots. Phytochemistry 23, 2121 (1984). 

Fastre RV, Luyengi L, Vanhaelen M, Declercq JP, Meerssche MV (1987) Two Quassinoids and Two Coumarinolignoids from Hannoa klaineana Roots. Phytochemistry 26 317... 

Francois G, Diakanamwa C, Timperman G, Bringmann G, Steenackers T, Atassi G, Looveren MV, Holenz J, Tassin JP, Assi LA, Vanhaelen-Fastre R, Vanhaelen M (1998) Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol 28 635-640... 

Since then, seven more C25 quassinoids have been discovered Odyendane (215) and odyendene (216) from the Odyendea gabonensis [90], klaineanolide A (217) and B (218) from the Hannoa klaineana [61], indaquassin F (219) from the Quassia indica [80], javanicinoside E (220) isolated from the Picrasma javanica [76] and the new epimer from simarolide (221) [91],... 

Hannoa chlorantha and Hannoa klaineana are used in traditional medicine of Central African countries against fevers and malaria. Four stem bark extracts from H. klaineana and for quassinoids from H. chlorantha were examined in vitro against P. falciparum NF 54 [100],... 

Lumonadio et al. isolated five quassinoids from the root bark of Hannoa klaineana. Of these quassinoids, only 15-desacetyl-undulactone (70) was active against P-388 mouse lymphocytic leukemia cells and colon 38 adenocarcinoma in mice. Undulactone (71) and especially 15-0-"-D-glucopyranosyl-21-hydroxy-glaucarubolone (72) were more toxic, while 6a-tigloyloxy-glaucarubol (73) and 21-hydroxy-glaucarubolone (74) were inactive [27]. 

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