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Halogenation selective bromination

Halogen-substituted succinimides are a class of products with important appHcations. /V-Bromosuccinimide [128-08-5] mp 176—177°C, is the most important product ia this group, and is prepared by addition of bromine to a cold aqueous solution of succinimide (110,111) or by reaction of succinimide with NaBr02 iu the presence of HBr (112). It is used as a bromination and oxidation agent ia the synthesis of cortisone and other hormones. By its use it is possible to obtain selective bromine substitution at methylene groups adjacent to double bonds without addition reactions to the double bond (113). [Pg.536]

Principles and Characteristics Combustion analysis is used primarily to determine C, H, N, O, S, P, and halogens in a variety of organic and inorganic materials (gas, liquid or solid) at trace to per cent level, e.g. for the determination of organic-bound halogens in epoxy moulding resins, halogenated hydrocarbons, brominated resins, phosphorous in flame-retardant materials, etc. Sample quantities are dependent upon the concentration level of the analyte. A precise assay can usually be obtained with a few mg of material. Combustions are performed under controlled conditions, usually in the presence of catalysts. Oxidative combustions are most common. The element of interest is converted into a reaction product, which is then determined by techniques such as GC, IC, ion-selective electrode, titrime-try, or colorimetric measurement. Various combustion techniques are commonly used. [Pg.595]

Kamikawa et al. chose the first option to generate the benthocyanin skeleton [91]. To begin with, 100 and aniline 126 are transformed into o-nitrodi-phenylamine 127 by intermolecular N-arylation. Reduction of the nitro group and selective bromination produces 128, and this time an intramolecular Buch-wald-Hartwig reaction is used to derive a mixture of the desired phenazine 129 and the elimination product 130. The fundamental problem with this approach relates to the selective introduction of the halogen substituent that is required for the intramolecular N-arylation. [Pg.108]

The additivity treatment also allows one to evaluate the influence of substituents which are otherwise obtainable only with difficulty. The study of the non-catalytic bromination of the halo-substituted poly-methylbenzenes by Illuminati and Marino (1956) allowed the evaluation of the partial rate factors for the highly deactivating m- and p-halogens. These data for the slow, highly selective bromination are inaccessible by other techniques. Analysis of the relative rates is made by application of the additivity equations (5) and (6) as described in Section I. An important aspect of the chemistry of the substituted polymethyl-benzenes, in contrast to the monosubstituted benzenes, is the large difference in p for bromination. The partial rate factors derived for each reaction are correlated with good precision by the tr4 -constants (Figs. 11 and 19). Yet the susceptibility of the reactions to the influence of substituents is altered by more than 25%. As already noted, this aspect of the problem is not well defined and is worthy of additional attention. [Pg.139]

The higher homologues of toluene such as ethylbenzene are not usually halogenated selectively and mixtures are often produced (see Chapter 3). In the case of ethylbenzene itself, the major product of chlorination is the 1-substituted product (56%). Bromine is more selective and the 1-bromo derivative 7 is formed exclusively. [Pg.111]

A problem arises at this point how do we brominate the Cs-Cs double bond without brominating the C22-C23 double bond at the same time If we compare the two double bonds, we will see that the Cs-Ce double bond is trisubstituted, while the C22-C23 double bond is disubstituted. To see how this will help us selectively brominate the Cs-Ce double bond, we must look at the mechanism for addition of halogens to alkenes. When a halogen molecule is near a double bond, it becomes polarized ... [Pg.1162]

The environmental scrutiny that has impacted halogenated flame retardants has primarily focused on brominated diphenyl oxides such as DBDPO. There is concern that these compounds release dioxins when burned. Activity has primarily been in Europe. Currently there are no legislative bans or limits on halogenated flame retardants anywhere in the world, and there are not any on the near-term horizon. However, there are some voluntary bans on selected brominated compounds (particularly DBDPO and related types) in some of the green countries of Europe. In many cases, these brominated products are replaced by other brominated products that are not under immediate suspicion. [Pg.273]

Zeolites can facilitate the shape-selective bromination of olefins. When a mixture of cyclohexene and oct-2-ene are reacted with bromine the two alkenes are brominated to a similar extent. However, when the zeolite catalyst silicalite-1 is present the reaction becomes selective [143]. This selectivity depends upon the order in which the reactants are introduced to the catalyst. If the alkene mixture is stirred with the zeolite prior to the addition of bromine then the straight chain octene enters the zeolite pores. The more bulky cyclohexene remains in solution and is halogenated in preference to the octene when the bromine is introduced. If the bromine is pre-absorbed on the zeolite before the alkene mixture is added then the selectivity of the process is reversed [144]. [Pg.106]

Although both brominated and chlorinated epoxide resins have been used, the preferred halogen is bromine. This is because less bromine (by weight) is required to impart flame retardancy than with chlorine. Another important reason for the selection of bromine in preference to chlorine is thermal stability. [Pg.125]


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Bromination selective

Bromine selectivity

Halogenations bromine

Halogens bromine

Selective halogenation

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