Halobetasol

Halobetasol propionate Cream, ointment 0.05 Very high I... 

Halobetasol (Ultravate) Corticosteroid Cream, oint 0.05% [15. 45 gm] Apply to affected area bid... 

Do not use occlusive dressings in augmented betamethasone dipropionate, betamethasone dipropionate, clobetasol, halobetasol propionate, and mometasone treatment regimens. 

Halobetasol Ultravate cream, oint 0.05% Very high... 

Examples of group I, i.e. weak or low efficacy topical steroids, are hydrocortisone acetate in various concentrations, methylprednisolone 1.0% and prednisolone 0.5%. Group II, the moderately potent steroids, includes alclometasone dipropionate 0.05%, hydrocortisone butyrate 0.1%, triamcinolone acetonide 0.025% and fluocinolone ace-tonide 0.01%. Group III, the potent steroids, contains among others betamethasone valerate 0.1%, betamethasone dipropionate 0.05%, budesonide 0.025%, desoximetasone 0.05%, fluticasone propionate 0.05%, amcinonide 0.1%, fluocinonide 0.05% and mometasone furoate 0.1%. Group IV comprises the very potent agents such as clobetasol propionate 0.05% and halobetasol propionate 0.05%. 

A substitution with another halogen at C-2 halomethasone, halopredone) or at C-21 (21-OH 21-CI) (clobetasol, halobetasol). Fluclorolone is an atypical fluorocorticosteroid, in which the 11jS-OH and the 9a-F are replaced by chlorine atoms (Fig. 51). 

Overdosage can occur from topically applied halobetasol absorbed in sufficient amounts to produce systemic effects producing reversible adrenal suppression, manifestations of Cushing s syndrome, hyperglycemia, and glucosuria in some patients,... 

FLUORINECOMPOUNDS,ORGANIC - FLUORINATED ALIPHATIC COMPOUNDS] (Vol 11) 21-Chloro-6a,9-difluoro-llb-hydroxy-16b-methyl-17-(l-oxopropoxy)-pregna-l,4-diene-3,20-dione. See Halobetasol propionate. 

Scientists at Ciba-Geigy synthesized a series of polyhalogenated corticosteroids, and one compound in the series containing halogen atoms at three positions -halobetasol propionate - was selected for further evaluation [41,42]. 

Halobetasol propionate is a class I topical corticosteroid, or an ultrapotent corticosteroid according the Stoughton classification system which is widely used in United States. Halobetasol propionate has been approved in the United States for the treatment of corticosteroid-responsive dermatoses. In a number of clinical studies, halobetasol propionate cream and ointment have both been tested against vehicle and compared with other ultrapotent corticosteroids [43]. 

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