Tumors growth kinetics

Huang SM, Harari PM. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin Cancer Res 2000 6 2166-2174. 

The most reasonable approach for addressing this dilemma is to exploit differences in cell growth kinetics between cancer cells and host cells. A hallmark of cancerous cell growth is the rapidity of its cellular proliferation. At any given time, a malignant tumor should have more cells undergoing mitosis and replication than other tissues in the host. 

The search of optimal scheme of cytostatics application is the most complex. Experience shows that it is possible to find the optimal solution only at careful analysis of growth of intact tumors which is determined by particularities of growth kinetics. 

One of the first kinetic models was formulated by Skipper et. al. (Skipper-Schabel-Wilcox) [7] on the base of data of observation for mousse with leucaemia L1210. the growth of this tumor may be described by exponential law ... 

The Gompertz equation is often used for description of tumors growth kinetics ... 

In other cases the kinetics of tumors growth is described by equation of auto-catalysis (in biology it is logistic Verhulst equation) ... 

Gomperts kinetics is the feature of effective homeo-static system at the size close to plato the growth is decelerated and tumor becomes resistant to cytostatic agents, but in the case of size decrease the growth is restarted and it reach previous size fast. As a consequence, the tumors growing in accordance with Gomperts kinetics are hardly totally eliminated out of organism. 

Figure 7. Kinetic graph of ecotoxicological model of tumor growth of equations system (37) solution.

Animal-Model, Tumoe-to-Noemal Tissue Ratios, Lasee Light Dose, Blood Cleaeance Kinetics, and Tumor Growth Delays to... 

The cell-kill hypothesis states that the effects of antitumor drugs on tumor cell populations follow first-order kinetics. This means that the number of cells killed is proportional to the dose. Thus, chemotherapy follows an exponential or log-kill model in which a constant proportion, not a constant number, of cancer cells are killed. Ilieoretically. the fractional reductions possible with cancer chemotherapy can never reduce tumor populations to zero. Complete er ica-tion requires another effect, such as the immune response. A modified form of the first-order log-kill hypothesis holds that tumor regressions produced by chemotherapy are de-.scribed by the relative growth fraction present in the tumor at the lime of treatment This idea is consistent with the finding that very small and very large tumors are less responsive than tumors of intermediate size. ... 

The involvement of milk protein-derived cytomodulatory peptides to determine the viability of cancer cells is a field of great interest. Commercial yoghurt starter cultures hydrolyse casein to produce bioactive peptides that control colon cell kinetics in vitro. Bioactive sequences of casein modulate cell viability in different human cell cultures. Peptides from an extract of Gouda cheese inhibited growth of leukemia cells even at 1 pmol/L [223]. They were able to induce apoptosis in the tumor cells. Cancer cells are more reactive to peptide-induced apoptosis than non-malignant cells [224]. Casein-derived peptides could have a role in the prevention of colon cancer by blocking proliferation of the epithelium and by... 

Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents. Cancer Res 64 1094-1101 (2004). 

FIGURE 124-5. Gompertzian kinetics tumor-growth curve relationship to symptoms, diagnosis, and various treatment regimens. (Reproduced with permission from BuickJ" )... 

Tumor growth fraction is inversely related to tumor population site. Therefore, optimal kinetic conditions to achieve cure with chemotherapy exist in the setting of micro metastatic disease. 

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