Growth of tumor cells

Representatives of the l-benzylidene-[l,4]oxazino[3,4- ]quinazolin-6-ones prepared from 315 exhibit remarkable protein-tyrosine kinase inhibitory activity and inhibit the growth of tumor cells <1996BMC547, 2001USP6331555, 2002BBA318>. 

This was the first report of the successful screening of antibiotics for antitumor activity. Antibiotic research was thus expanded to also cover antitumor research. The term antitumor antibiotics was coined to include those compounds that are produced by microorganisms and inhibit the growth of tumor cells and tumors. Since that time, I have been continuing the study of new antitumor 2Uitlbiotics. Up to now with my collaborators I discovered eibout 65 antitumor antibiotics and elucidated structures of about 50 of them. Among them, bleomycin which we discovered in 1966 (76,79) has been used in the treatment of Hodgkin s lymphoma, tumors of the testis, and carcinomas of the skin, head, neck, and cervix. 

Inhibition of these prenyltransferases blocks growth of tumor cells. Many prenyltransferase inhibitors are apparently nontoxic to normal cells and are undergoing human clinical trials as anticancer drugs.763 79a b Among other important polyprenyl... 

Thus, the development of new anthracycline antibiotics is of interest in which the therapeutical width is enhanced by decreasing toxicity and increasing specificity. Several screening methods are presently available in clinical tests. One is carried out by measurement of the survival rate of mice, induced with P 388 leukemia carcinoma [30, 32], Other methods are based on in-vitro tests either the 50% inhibitory concentration (IC50) of nucleosomal RNA synthesis is measured or the growth of tumor cell cultures like He La is observed [34],... 

Leukine increases the cytotoxicity of monocytes toward certain neoplastic cell lines and activates polymorphonuclear neutrophils to inhibit the growth of tumor cells... 

Bengamides were isolated originally as anthelmintic agents from a sponge Jaspis sp. Later, bengamide A (36) was found to inhibit growth of tumor cells as well as methionine aminopep-tidases (2). 

The feet that mutant Ras genes have been associated with a wide variety of human tumors suggests that they are responsible for the uncontrolled growth of tumor cells. Studies involving in vitro cell culture and transgenic animals have demonstrated the ability of... 

S. Lin and S. J. Danishefsky, Angew. Chem. Int. Ed., 2002, 41, 512. Proteasome inhibitors block the breakdown of proteins in the cell, and these may be effective in fighting the growth of tumor cells. 

Phorboxazole A and B are marine natural products isolated from recently discovered species of Indian Ocean sponge near Muiron Island, western Australia. The phorboxa-zoles are among the most cytostatic natural products known, inhibiting the growth of tumor cells at nanomolar concentrations. 

Wu,F., Grossenbacher, D., and Gehring, H. (2007) New transition state-based inhibitor for human ornithine decarboxylase inhibits growth of tumor cells. Mol. Cancer Ther. 6, 1831-1839. 

Pyrazomycin. Pyrazomycin (11), 3-(l-p-D-ribofuranosyl)-4-hydroxypyrazole 5-carboxamide, is isolated from S. Candidas (1—4,9,10). The incorporation of [2-13C]acetate and [1- and U-14C]glutamate into the four contiguous carbons of pyrazomycin has been reported (11,12). Pyrazomycin 5 -phosphate inhibits orotidylic acid decarboxylase. Pyrazomycin inhibits adenosine phosphorylation and decreases the incorporation of deoxyuridine into DNA of Novikoff hepatoma cells in culture. It also inhibits the growth of tumor cells and the cytopathic effects of vaccinia, herpes simplex, vesicular stomatitis, Newcasde disease, measles, Sindbis, polio, hepatitis A, and coxsackie viruses (13,14). The inhibitory action of (11) on viral multiplication is reversed by uridine. 

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