Growth inhibition activity

When reacted with dimethyl acetylenedicarboxylate, the amines produced ben-zotriazolylaminobutendioates 188 accompanied by A-benzotriazolyl substituted 2-pyridones only in the case of 5-amino-2-methyl-2//-benzotriazole, the triazolo-9,10-dihydrobenzo[d]azepine and an unusual cyclization product, triazolo-2-oxindole (convertible into 2-methyltriazolo[4,5-/]carbostyril-9-carboxylate) were formed. The quinolones 189 were aromatized to chloroesters 190 these in turn were hydrolyzed to chloroacids 191 and decarboxylated to 9-chlorotriazolo[4, 5-/]quinolines 192 (Scheme 58) (93H259). The chlorine atom could be replaced with 17 various secondary amines to give the corresponding 9-aminoalkyl(aryl) derivatives 193, some of which exhibit both cell selectivity and tumor growth inhibition activity at concentrations between 10 and 10 " M (95FA47). 

A copper(II) complexes of 5-phenylazo-3-methoxy salicylidene thiosemicarbazone has been shown to have promising growth inhibition activity against P388 lymphocytic leukemia cells sensitive and resistant to adriamycin [196], The complex involves ON coordination of two deprotonated ligands and v(CS) is reported to be unaltered in intensity and position in the complex from its position in the spectrum of the ligand. Inhibition studies with the uncomplexed thiosemicarbazone indicating an important role for the copper(II). 

Table 1. Unsaturated Lactones with Plant Growth Inhibiting Activity...

Comparative study on modeling growth inhibition activity using physicochemical and connectivity indices... 

Keywords Growth inhibition activity, QSAR, physicochemical parameters, connectivity indices, MLR... 

Yoshimura H, Takegami K, Doe M, Yamashita T, Shibata K, Wakabayashi K, Soga K, Kamisaka S (1999) a-Amino Acids from a Mushroom, Amanita castanopsidis Hongo, with Growth-Inhibiting Activity. Phytochemistry 52 25... 

The northeast Pacific bryozoans Phidolopora pacifica contained two nitrophenols, desmethylphidolopin (448) and 3-nitro-4-hydroxybenzyl alcohol (449) (365). Desmethylphidolopin (448) showed antimicrobial activity. 2-Amino-6-[(r/ ,2 5)-l, 2 -dihydroxypropyl]-3-methyl pterin-4-one (450) was isolated from the anthozoan Astroides calycularis collected in the Bay of Naples and exhibited cell growth-inhibiting activity (366). The structure of leucettidine, a pteridine derivative found in Leucetta microra-... 

Growth inhibition activities Epicotyls of bean seedlings were treated and changes in the geotropic reaction were recorded. 

Sesquiterpenes such as 8-caryophyllene, bisabolene and chamazulene found in Artemisia absenturium were shown to possess growth-inhibiting activity (92). Other artemisia species (A. psilastachya and A. acanticarpa) produce several sesquiterpenes, some of which may also be growth inhibitors (93, 94). 

Bacterial signal peptidase is an example of a known enzyme that could serve as a target for new antibacterial agents [13], Recently, a catalytically active, soluble fragment of signal peptidase from E. coli has been crystallized as a complex with a P-lactam inhibitor [69], This represents a major step in the efforts toward the rational design of inhibitors that can be readily tested for their enzyme inhibition and bacterial growth-inhibition activities. 

The first evidence for aminocarbapyranoses occurring in Nature dates back to early 70s with the discovery of validamine 202 (Chart 3), a carbasugar constituent of Validamycins, an antibiotic complex which shows growth inhibition activity against bacterial diseases of rice plants [50]. Shortly after, validamine 202, along with valiolamine 203 and valienamine 204, (Chart 3), were isolated from the fermentation broth of Streptomyces hygroscopicus var. limoneus [50],... 

New drugs suspected of having anticancer activity are tested in standard animal models in which tumors are transplanted from one generation of animals, generally mice, to the next and are thus perpetuated in vivo. In vitro tumor cell culture systems are commonly used to determine if a new drug has cytotoxic or growth-inhibiting activity. However, the in vivo test is considered to be a better predictor of activity in humans. 

Thompson, A.C. et al 1987. Indoleall l-amines ckDesmanthus iilinoensisisiA their growth inhibition activity Journal of Agricultural and Food Chemistry 35(3) 361-365. 

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