Growth Hormone Sodium

Endocrine and metabolic Blood tests Serum concentrations of pituitary horrmones (TSH, LH, FSH, ACTH, growth hormone, prolactin, vasopressin) serum concentrations of other hormones (insulin parathyroid hormone, glucagon, calcitonin, vitamin D) and serum electrolyte concentrations (sodium, potassium, calcium, magnesium)... 

Wu S-Y, Robinson JR (1999) Transcellular lipophilic complex-enhanced intestinal absorption of human growth hormone. Pharm Res 16 1266-1272 Yamashita S, Saitoh H, Nakanishi K, Masada M, Nadai T, Kimura T (1987) Effects of diclofenac sodium and disodium ethylenediaminetetraacetate on electrical parameters of the mucosal membrane and their relation to the permeability enhancing effects in the rat jejunum. J Pharm Pharmacol 39 621-626... 

In a pharmacokinetic-based study by Hedin et al. [94], hGH was administered with a nasal permeation enhancer, sodium tauro-24,25-dihydrofusidate (STDHF), in patients deficient in growth hormone (GH) using a reprocessed lyophilized form of hGH. The lyophilized material was formulated with STDHF and all the subjects received the formulation by both the nasal and subcutaneous routes. The dose given by the subcutaneous route was a standard dose of O.lIU/kg body weight (BW), whereas three different doses (of 0.2,0.4, and 0.8 IU/kg BW) of the nasal formulation were given. As compared with the subcutaneous route, all three nasal formulations showed a rapid increase in the plasma levels of hGH, with Y rn ix being reached 15-25 min after administration, as compared with 3-4 h in the case of the subcutaneous route. However, the Cmax was higher in the case of the latter route, and the nasal formulations touched baseline after 3-4 h, as compared with 14-18 h after subcutaneous delivery. 

Abbreviations PLGA poly(lactide-co-glycolide) P(CPP CEFB) poly[l,3-bis(p-carboxy-phenoxy) propane-co-p-(carboxyethylformamido) benzoic anhydride] chitosan-TBA chitosan-4-thiobutylamidine conjugate LPC lysophosphatidyl choline hGH human growth hormone GDC glycodeoxycholate sodium STDHF ... 

A procedure for the slow and sustained release of the growth hormone inhibitor Lanreotide is described. The method entails incorporating Lanreotide to the isocitric acid lactone component on the backbone of a polyester block copolymer using sodium hydroxide as the saponification agent. 

As an illustration of HIC technique, the recombinant human growth hormone (hGH) and methionyl hGH (met-hGH) were well-separated by the HIC technique [14]. The optimized conditions were found to be IM ammonium phosphate dibasic, pH 8.0/propanol (99.5 0.5) and 0.1 M sodium phosphate dibasic, pH 8.0/propanol (97.5 2.5) for mobile phase A and B, respectively, with a descending gradient from 100% A to 100% B in 30 minutes at a column (TSK-phenyl 5PW, 75 x 7.5 mm) temperature of 30°C. Note that the addition of a small amount of propanol as organic modifiers significantly decreases elution time while maintaining resolution and efficiency. This HIC method allowed separation of several hGH variants from the main hGH peak while retaining their native structures. 

Figure 5 Effect of excipients on the storage stability of freeze-dried human growth hormone (hGH). Samples were stored for I month at 40°C. Solid bars, aggregation (primarily dimer). Hatched bars, chemical degradation via methionine oxidation and asparagine deamidation. The glass transition temperatures of the initial freeze-dried formulations are given above the bars when a gla.ss transition temperature could be measured by DSC. The glycine mannitol formulation is a weight ratio of hGH glycine mannitol of 1 1 5, the dex-tran formulation is 1 6 hGH dextran 40, none means no stabilizer, and the others are 1 1 hGH stabilizer. All formulations contain sodium phosphate buffer (pH 7.4) at 15% of the hGH content. Initial moisture contents are all ==1%. (Data from [4].)...

Zomacton human pituitary growth hormone, zomepirac [ban, inn] (zomepirac sodium [usan] ... 

Koulu M, Lammintausta R, Kangas L, Dahlstrom S. The effect of methysergide, pimozide and sodium valproate on the diazepam-stimulated growth hormone secretion in man. J Clin Endocrinol Metab 1979 48 119-22. 

Hahn SK, Kim SJ, Kim MJ, et al. Characterization and in vivo study of sustained-release formulation of human growth hormone using sodium hyaluronate. Pharm Res 2004 21(8) 1374-1381. 

Trans. I 1975, 2243 M. Miyano, J. Org. Chem. 46, 1846 zona glomerulosa and transported chiefly by alhumm In man, 400 secreted normally in one day, Secretion influenced by ACTH, growth hormone plasma sodium and potassium, and the renin-angiotensin system. Causes reabsorption of N i +, Cl-, and HC03" and diuresis of K+. Review L. F. Fieser, M. Fieser, Steroids (Reinhold New York, 1959) pp 701-720. 

Kim S J, Hahn S K, Kim M J, et al. (2005). Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles. /. Controlled Rel. 104 323-335. 

Castor bean lipase is inhibited by thiourea and formaldehyde, being more sensitive than pancreatic lipase to these agents (3.51), by sodium fluoride (363), and by chloral hydrate and urethan in high concentration (364). Plant growth hormones, such as 2,4-dichlorophenoxyacetic acid (365, 366), are stated to inhibit castor bean lipase, but have also been described as activators (334). 

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