Zomepirac sodium

Infra-red Spectrum. Principal peaks at wavenumbers 1587,1560, 760,1275,958,1493 (zomepirac sodium, KBr disk). 

In a fatality due to the ingestion of 9 g of zomepirac sodium, a postmortem blood concentration of 152 pg/ml and an antemortem blood concentration, obtained 9 hours prior to death, of 286 pg/ml were reported (R. C. Backer etal., J. analyt. Toxicol., 1983, 7, 223-224). 

Dose. Zomepirac sodium has been given in doses equivalent to 400 to 600 mg of zomepirac daily. 

Diloxanide Furoate T ricyclamol Chloride 349.7 Zomepirac Sodium... 

Zomepirac Sodium Dequalinium Chloride Conessine Hydrobromide... 

Zomacton human pituitary growth hormone, zomepirac [ban, inn] (zomepirac sodium [usan] ... 

The addition sequence may determine the primary reaction course or influence impurity formation. For example, condensation of diethyl 3-oxoglutarate 33 with chloroacetone and methylamine is expected to give the 5-methylpyrrole 34, the Hantzch pyrrole product (Figure 5.14). The isomeric 4-methylpyrrole 35 (a precursor to zomepirac sodium) was prepared in good yield by first treating 33 with methylamine, then adding chloroacetone [22]. The addition sequence was also important for the chlorination of the sulfinate anion 36 The dimer 37 was produced when N-chlorosuccinimide was added to the reaction, but when 36 was added slowly to excess Cl2, the desired sulfonyl chloride 38 was produced (Figure 5.14) [23], The course of these reactions may be predicted if one takes a mental snapshot of them. 

K meprobamate L norpseudoephedrine M noscapine N papaverine 0 paracetamol P paraquat Q phencyclidine R phenobarbltone S sulphanllamide T zomepirac sodium salt. 

This eonstitutes an important class of non-steroidal anti-inflammatory drugs which have gained reeognition in the reeent past. A few classieal examples of this group are, indomethacin sulindac tolmetin sodium zomepirac sodium ... 

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