Granulocyte-CSF

G-protein-coupled Receptor Kinases (GRKs) G-protein-coupled Receptors G-proteins and Wnt Signaling Granulocyte-CSF (G-CSF) Granulocyte-macrophage-CSF (GM-CSF)... 

Granulocyte CSF was first identified (as CSF-/J) in placenta-conditioned medium and was shown to induce the differentiation of murine myelo-... 

Macrophage CSF — stimulates macrophage production Granulocyte CSF (/ -CSF) stimulates granulocyte production GMCSF (a-CSF) — stimulates production of macrophages and granulocytes... 

Pui CH, Boyett JM, Hughes WT, et al. Human granulocyte CSF after induction chemotherapy in children with acute lymphoblastic leukemia. N Engl J Med 1997 336 1781-1787. 

K27. Kreider, B. L., Phillips, P. d., Prystowsky, M. B., Shirsat, N., Pierce, J. H., Tushinski, R., and Rovera, G. Induction of the granulocyte-macrophage colony-stimulating factor (CSF) receptor by granulocyte CSF increases the differentiative options of a murine hematopoietic progenitor cell. Mol. Cell. Biol. 10,4846-4853 (1990). 

For a nnmber of years, S. cerevisiae was the only yeast used for the industrial production of recombinant proteins. However, other organisms, snch as Pichia pastoris came upon the scene for prodnction of posttranslation modified proteins. S. cerevisiae possesses several properties analogons to those of E. coli. Usnally, the yeast appears more convenient to use when the target protein is not prodnced in a soluble form by the prokaryotic system. A few peptides, such as insulin, human growth hormone, and granulocyte-CSF, are produced by both S. cerevisiae and E. coli, whereas S. cerevisiae alone hosts the production of almost all the approved recombinant vaccines (17 products compared to one by E. coli) (Ferrer-Miralles et al. 2009). 

The role of cytokine therapy in the management of radiation accident victims has been summarized (152). In GoiBnia in Brazil in 1987, eight radiation accident victims were treated with GM-CSF one month after radiation exposure. Marked increases in granulocyte production were induced in five persons, although this did not prevent death. 

G-CSF Granulocyte colony-stimulating factor GDP Guanosine 5 -diphosphate GEC Glomerular epithelial cell GF-1 An insulin-like growth factor GFR Glomerular filtration rate... 

Erythropoiesis is a process that starts with a pluripotent stem cell in the bone marrow that eventually differentiates into an erythroid colony-forming unit (CFU-E)4 (Fig. 63-1). The development of these cells depends on stimulation from the appropriate growth factors, primarily erythropoietin. Other cytokines involved include granulocyte-monocyte colony-stimulating factor (GM-CSF) and interleukin 3 (IL-3). Eventually, the CFU-Es differentiate into reticulocytes and cross from the bone marrow into the peripheral blood. Finally, these reticulocytes mature into erythrocytes after 1 to 2 days in the bloodstream. Throughout this process, the cells gradually accumulate more hemoglobin and lose their nuclei.4... 

G-CSF Granulocyte colony-stimulating factor HS At bedtime horn somni)... 

GM-CSF Granulocyte-macrophage colony-stimulating factor ID Identification infectious disease... 

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