Colony-forming unit erythroid

The development of colony-forming unit-erythroid of bone marrow from male Swiss-... 

Erythropoiesis is a process that starts with a pluripotent stem cell in the bone marrow that eventually differentiates into an erythroid colony-forming unit (CFU-E)4 (Fig. 63-1). The development of these cells depends on stimulation from the appropriate growth factors, primarily erythropoietin. Other cytokines involved include granulocyte-monocyte colony-stimulating factor (GM-CSF) and interleukin 3 (IL-3). Eventually, the CFU-Es differentiate into reticulocytes and cross from the bone marrow into the peripheral blood. Finally, these reticulocytes mature into erythrocytes after 1 to 2 days in the bloodstream. Throughout this process, the cells gradually accumulate more hemoglobin and lose their nuclei.4... 

Figure 2.2. Role of cytokines in blood-cell development. Abbreviations CFU, colony-forming unit CFU-GEMM, granulocyte-erythroid-monocyte-megakaryocyte CFU CFU-GM, granulocyte-macrophage CFU CFU-M, macrophage CFU CFU-G, granulocyte CFU CFU-Eos, eosinophil CFU IL, Interleukin. See text for details.

B cell bh4 bp BPI BSA C domain C1-C9 cAMP CAP CD cDNA CFU CFU-GEMM bone-marrow-derived lymphocyte tetrahydrobiopterin base pairs bactericidal/permeability-inducing protein bovine serum albumin constant domain complement components cyclic adenosine monophosphate cationic antimicrobial protein cluster of differentiation complementary deoxynucleic acid colony-forming unit granulocyte-erythroid-monocyte-megakaryocyte CFU... 

FIGURE 98-3. Proposed differentiation pattern of cells into mature erythrocytes with identification of various immature cell types. In addition, the cells that may be stimulated by the cytokine erythropoietin (EPO) are identified. BM, bone marrow BFU, burst-forming unit CFU, colony-forming unit E, erythroid EB, erythroblast OC, orthochromatophilic PB, peripheral blood PC, polychro-matophilic RBC, red blood cell retie, reticulocyte. 

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