Granulate filling

The BFS technology is an advanced aseptic processing technique which allows plastic containers to be formed by means of molded extruded polymer granules, filled, and sealed in one continuous process. This differs from conventional aseptic processing where container formation, preparation, and sterilization, and container filling and closiu e are all separate processes. 

Screen the flavor through a 600-micron-aper-ture screen with an equal portion of granulation. Fill into suitable approved bottles at the theoretical fill weight. 

Granulate mixture I with solution II and pass through a 0.8 mm sieve to obtain free-flowing granules. Fill 2 g in sachets or 20 g in a 100 ml flask. 

The granulate-filled sandwich structure described in Section II.B permits continuously operated loop systems to be developed as replacements for batch processes. Loop reactors so equipped also exhibit advantages by comparison to conventional fixed-bed reactors better exploitation of the catalytically active component due to smaller granulate size, lower pressure drop, and better gas-liquid mass transfer. 

Blow-fill technology is an aseptic process whereby the container is formed from thermoplastic granules, filled with sterile solution and sealed, all within one automatic operation. The bulk solution should have a low bioburden and is delivered to the machine through a filling system that has been previously sanitized and steam sterilized in situ. Concern has been expressed that the machine itself may generate particles. The plastic granules are composed usually of polyethylene, polypropylene or one of their copolymers and are heat extruded at 200°C into a tube. The two halves of a mould close around this tube and seal the base. The required quantity of sterile fluid is filled into the container, which is then sealed. Products packed in this way include intravenous solutions, and small volume parenteral, ophthalmic and nebulizer solutions. The... 

Blow/fill/seal units are purpose built machines in which, in one continuous operation, containers are formed from a thermoplastic granulate, filled and then sealed, all by the one automatic machine. Blow/fill/seal equipment used for aseptic production which is fitted with an effective grade A air shower may be installed in at least a grade C environment, provided that grade A/ clothing is used. The environment should comply with the viable and non-viable limits at rest and the viable limit only when in operation. Blow/fill/seal equipment used for the production of products for terminal sterilisation should be installed in at least a grade D environment... 

Blow/Fdl/Seal Technology Blow/fill/seal units are specialist purpose built equipment in which, in one continuous operation, containers are formed from thermoplastic granule, filled and then... 

The chromium (II) salt solution is obtained in a Zn reductor (see previous preparation). This consists of a glass tube a (45 cm. long and 2 cm. I.D.) in which a glass wool plug is inserted at b. The Zn granules filling the tube are amalgamated before use... 

Two common reduction columns are used. In the Jones reductor the column is filled with amalgamated Zn prepared by briefly placing Zn granules in a solution of ITgCb to form Zn(lTg). Oxidation of the amalgamated Zn... 

Direct Compression. This process is relatively simple and time saving. AH the ingredients are blended and then compressed into the final tablet. This is an excellent method, but encumbered by a number of problems. Not all substances can be compressed directly, necessitating a granulation step. Likewise, the flow properties of many blends of fine, particle-sized powders are not such as to ensure even filling of the die cavities of tablet presses. In addition, air entrapment can occur. 

The actual compression process is a cycle of die fill, compaction by intervention of the upper punch using great pressure on the granulation material in the die, and upward movement of both punches to achieve ejection of the tablet from the die. Singe-punch presses have only one die-and-punch arrangement and the compression is quick, with Httle dwell time of the top punch in die. 

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