Filling Technology

Y. Harada, K. Fushimi, S. Madokoro, H. Sawai, and S. Ushio, The characterization of via-filling technology with electroless plating method, J. Electrochem. Soc. 133, 2428, 1986. 

Blow-fill technology is an aseptic process whereby the container is formed from thermoplastic granules, filled with sterile solution and sealed, all within one automatic operation. The bulk solution should have a low bioburden and is delivered to the machine through a filling system that has been previously sanitized and steam sterilized in situ. Concern has been expressed that the machine itself may generate particles. The plastic granules are composed usually of polyethylene, polypropylene or one of their copolymers and are heat extruded at 200°C into a tube. The two halves of a mould close around this tube and seal the base. The required quantity of sterile fluid is filled into the container, which is then sealed. Products packed in this way include intravenous solutions, and small volume parenteral, ophthalmic and nebulizer solutions. The... 

K-C. Fan, J.-Y. Chen, C.-H. Wang, and W.-C Pan Development of a drop-on-demand droplet generator for one-drop-fill technology. Sensors and Actuators A, 147, 649-655 (2008). 

Some common failure mechanisms, which Ulustrate the risk associated with fill technology, are shown in Fig. 27.22. Here, micrographs show a via fill with a lack of plating adhesion and wrap copper, allowing interconnect separation. 

Fabrication and role of each constituent of the SiCf/SiC composite and matrix filling technologies... 

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