Aseptic processing conventional

The BFS technology is an advanced aseptic processing technique which allows plastic containers to be formed by means of molded extruded polymer granules, filled, and sealed in one continuous process. This differs from conventional aseptic processing where container formation, preparation, and sterilization, and container filling and closiu e are all separate processes. 

This section describes the conventional manned clean room a later section in this chapter will address alternative aseptic processing environmental control designs with somewhat different features and control measures. 

Basic Environmental Standards Aseptic Areas For aseptic processing, rooms with conventional filtered airflows and with contained work stations in the form of filtered air hoods or laminar air flow protection at working points are usually more appropriate than laminar air flow rooms. 

The United States Pharmacopeia USP 35 (2012) The United States Pharmacopeial Convention. Rockville. <1116> Microbiological control and monitoring of aseptic processing environments... 

In summary, we conclude that a minimum M-1 yield of 3.0 mM from the initial glucose concentration of 0.56M (0.54% conversion) can be used to assure achievement of a minimum F -value of 3 in aseptic processing. The model suggests that the actual lethality will exceed the prediction based on the quadratic model due to the difference in the temperature profile. This chemometric approach needs to be tested using an industrial aseptic processing equipment. In ohmic heating, where the temperature increases much faster than in conventional aseptic processing, a different model needs to be used. 

Low-fat spreads with 40% fat content and containing protein usually have a shelf life of 8-10 weeks and water-based low-fat spreads of about 4 months based on storage at temperatures below 10°C (50°F) (90) (see Section 5.1). Very low fat spreads with fat contents below 20% and with a water continuous emulsion character require low pH, ultra high temperature processing, and possibly aseptic filling procedures to allow closed shelf lives comparable to conventional low-fat spreads (91). 

A flow diagram of the process is presented in Figure 5.6. The surface culture process is so called because the fermentation takes place in shallow trays. The trays are conventionally stacked up to ten high and several stacks may be placed together in die same room. The requirements for die plant are simple limited cleaning of the room to produce aseptic conditions at the beginning and a facility to pass warm, moist air over the trays. 

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