Granular cell tumor

There was an increase in the incidence of benign testicular interstitial cell tumors and granular cell tumors in the cervix and vagina in rats. 

A histologically identical lesion occurs almost exclusively in female newborns or infants along the alveolar ridge, designated congenital granular cell tumor it differs from the adult variety by its complete lack of... 

FIGURE 4.32 Granular cell angiosarcoma Is an uncommon lesion with a differential diagnosis that Includes granular cell tumor, metastatic melanoma, and epithelioid leiomyosarcoma. 

Mazur MT, Shultz JJ, Myers JL. Granular cell tumor Immunohistochemical analysis of 21 benign tumors and one malignant tumor. Arch Pathol Lab Med. 1990 114 692-696. 

Cavaliere A, Sidoni A, Ferri I, et al. Granular cell tumor An immunohistochemical study. Tumori. 1994 80 224-228. 

Kurtin PJ, Bonin DM. Immunohistochemical demonstration of the lysosome-associated glycoprotein CD68 (KP-1) in granular cell tumors and schwannomas. Hum Pathol. 1994 25 1172-1178. 

Filie AC, Lage JM, Azumi N. Immunoreactivity of SlOO protein, alpha-1-antitrypsin, and CD68 in adult and congenital granular cell tumors. Mod Pathol. 1996 9 888-892. 

Fine SW, Li M. Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. Am J Clin Pathol. 2003 119 259-264. 

MELANOMA VERSUS CUTANEOUS GRANULAR CELL TUMOR... 

Gleason BC, Nascimento AF. HMB-45 and Melan-A are useful in the differential diagnosis between granular cell tumor and malignant melanoma. Am J Dermatopathol. 2007 29 22-27. 

Ray S, Jukic DM. Cutaneous granular cell tumor with epidermal involvement a potential mimic of melanocytic neoplasia. J Cutan Pathol. 2007 34 188-194. 

One specialized type of reactive change is pseudo-epitheliomatous hyperplasia. This type of reaction can be found overlying a granular cell tumor but can also... 

ORAL CAVITY AND OROPHARYNX Granular Cell Tumor... 

The granular cell tumor (GCT) is an uncommon tumor of Schwann cell origin with a predilection for skin and mucosal surfaces, especially the tongue. Most are benign, but a few are malignant. The tumor is positive for S-100 protein, neuron specific enolase, alpha-l-antitrypsin, CD 68, vimentin, inhibin-alpha, protein gene product... 

Lassaletta L, Alonso S, Granell J, et al. Synchronous glottic granular cell tumor and subglottic spindle cell carcinoma. Arch Otolaryngol Head Neck Surg. 1998 124(9) 1031-1034. 

Barkan GA, Paulino AF. Are epidermal growth factor and transforming growth factor responsible for pseudoepitheliomatous hyperplasia associated with granular cell tumors Ann Diagn Pathol. 2003 7(2) 73-77. 

Le BH, Boyer PJ, Lewis JE, et al. Granular cell tumor immunohistochemical assessment of inhibin-alpha, protein gene product... 

Granular cell tumors are thought to be derived from Schwann cells and may occur as solitary pulmonary neoplasms.The neoplastic cells typically express... 

Dearers M, Guinee D, Koss MN, et al. Granular cell tumors of the lung Clinicopathologic study of 20 cases. Am J Surg Pathol. 1995 19 627-635. 

The most common cutaneous nerve sheath tumors are neurofibromas often, such tumors are multiple and occur in the setting of von Recklinghausen s neurofibromatosis. Neurilemmomas (schwannomas), granular cell tumors, perineuriomas, and neurothekeomas are represented in the skin as well. ° In contrast, malignant cutaneous peripheral nerve sheath tumors are... 

It is commonly accepted that most granular cell tumors (GCTs) of the skin show Schwann cell differentiation, but some examples of leiomyoma, leiomyosarcoma, BCC, and angiosarcoma also may demonstrate a granular-cell appearance. Accordingly, most (80%) but not all granular-cell tumors are reactive for... 

FIGURE 13.32 Granular cell tumor of the skin (A and B), demonstrating nucleocytoplasmic immunoreactivity for calretinin (C). 

Nikkels AF, Arrese-Estrada J, Pierard-Franchimont C, et al. CD68 and factor Xllla expressions in granular-cell tumor of the skin. Dermatology. 1993 186 106-108. 

Stefansson K, Wollman RL. SlOO protein in granular cell tumors (grantrlar cell myoblastomas). Cancer. 1982 49 1834-1838. 

Le BH, Boyer PJ, Lewis JE, et al. Granular cell tumor immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, SlOO protein, CD68, and Ki-67 proliferative index with clinical correlation. Arch Pathol Lab Med. 2004 128 771-775. 

Goldblum JR, Rice TW, Zuccaro G, Richter JE. Granular cell tumors of the esophagus a clinical and pathologic smdy of 13 cases. Ann Thorac Surg. 1996 62 860-865. 

Granular cell tumors are not too uncommon in the EHBT, especially in the common bile duct, and may be multicentric or coexist with granular cell tumors in other sites such as skin. These have the characteristic morphologic features of granular cell tumors arising elsewhere and are immunoreactive to S-100, NSE, Leu-7 (CD57), and vimentin. > ... 

FIGURE 18.2 Vulvar granular cell tumor (A). (H E.) Tumor cells (inset A) express S-100 (B), calretinin, and inhibin (not shown). 

Granular cell tumors may occasionally arise in the vulva. Their appearance is similar to tumors at other anatomic sites. They are thought to derive from peripheral nerve sheath and express S-100 protein, inhibin, and calretinin (Fig. 18.2). The diagnosis is usually straightforward but occasionally the differential may include melanoma, histiocytes, or even a decidual reaction. 

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