Gotu kola

Kola is not to be confused with gotu kola (Centella asiatica) (Gruenwald et al. 1998). Gotu kola is indigenous to Southeast Asia, and shows some antidepressant and sedative-like effects in animals, but has not yet been thoroughly researched. 

Gotu kola (Indian pennywort) Mental fatigue... 

Centella asiatica (L.) Urb. Ji Xue Cao (Gotu kola) (whole plant) Asiaticoside, madecassoside, brahmoside, brahmissoside, glucoside asiaticoside, sitosterol, tannin, vallarine, pectic acid, resin.33-450-510 Antibacterial, lower blood pressure, antipyretic, diuretic, detoxicant. 

Herbal Avoid valerian, St. John s wort, SAMe, kava kava, and gotu kola these may increase CNS depression. 

Gotu kola (Centella asiatica). A common herb of Southeast Asia, this creeping plant has been used for thousands of years in Ayurvedic medicine. Traditionally, it has been used as a diuretic, a cerebral tonic, and a treatment for leprosy as well as for inflammatory skin and muscle conditions. It is applied topically as a... 

Gotu kola (Centella asiatica, family Apiaceae)... 

A native of India and southeast Asia, it was traditionally used in Ayurvedic medicine. The most active ingredients are various triterpenoids that affect cells and tissues. In both laboratory and animal studies gotu kola extracts have shown anticancer effects. In Chinese medicine, luei gong gen. 

Gotu kola (dried above ground plant parts) memory, concentration... 

Centella asiatica Gotu Kola Indian pennywort, marsh penny, sheep rot... 

The herb gotu kola has the ability to promote wound healing. 

Gotu kola Hydrocotyle asiatica 1,3 CNS depression, dermatitis... 

Allergic contact dermatitis, confirmed by patch testing, has been reported after topical application of products containing gotu kola (Bilbao et al. 1995 Eun and Lee 1985 Izu et al. 1992 Morante et al. 1998 Santucci et al. 1985 Vena and Angelini 1986). 

No adverse effects on fetal development were observed in the offspring of mice administered fresh juice of gotu kola... 

Night eating syndrome was observed in a 41-year-old woman who had been taking a tincture of gotu kola (dose unspecified) for approximately 2 years. Onset of the syndrome was temporally associated with the use of gotu kola, and symptoms resolved after cessation of the tincture (O Brien 2005). 

Weak sensitization capacity of gotu kola was observed in guinea pigs after repeated topical application (Hausen 1993). 

No information on the safety of gotu kola during lactation was identified. While this review did not identify any concerns for use while nursing, safety has not been conclusively established. 

A reduction in conception rates was observed in mice orally administered fresh juice of gotu kola (equivalent to 20-80 g/kg of fresh plant) for either 14 or 21 days beginning 7 days prior to mating. Conception rates were approximately 45% for treated animals and 85% for untreated controls (Dutta and Basu 1968). 

Administration of ethanol, methanol, and w-butanol extracts but not a water extract of gotu kola to rats at doses of 28 ml/kg daily for 14 days inhibited in vitro platelet reactivity. The ethanol extract also inhibited dynamic coagulation (Satake et al. 2007). 

No information on the safety of gotu kola during lactation was identified. 

The LD50 of orally administered hydroalcoholic extract of gotu kola in rats could not be determined at doses up to 675 mg/kg (De Lucia et al. 1997). 

No adverse effects were observed in mice orally administered up to 1 mg/kg gotu kola aqueous extract daily for 15 days (Rao et al. 2005). 

Mutagenic activity of aqueous and ethanolic extracts of gotu kola was observed in Salmonella typhimurium strain TA98 with but not without metabolic activation (Mills and Bone 2005 Rivera et al. 1994). Conversely, weak to moderate inhibition of mutagenicity was observed in Salmonella... 

O Brien, B. 2005. Night eating s)mdrome and gotu kola. Iranian Med. J. 98(10) 250-251. 

Gossypimine. See Basic red 2 Gossypium. See Cotton (Gossypium herbaceum) Cottonseed (Gossypium) oil Gotu kola extract. See Hydrocotyl (Centella asiatica) extract... 

Synonyms Centella asiatica Centella asiatica extract Fo-ti-tieng extract Gotu kola extract Hydrocotyl asiatica extract Hydrocotyle asiatic extract Hydrocotylextract Definition Extract of the leaves and roots of the hydrocotyl, Centella asiatica Uses Botanical in cosmetics pharmaceuticals (anti-inflammatory/anti-irritant action in sun and eye care prods.)... 

Hisashi M, Toshio M, Hiroki U, Masayuki Y (2001) Medicinal foodstuffs. XXVI. Inhibitors of aldose reductase and new triterpene and its oligoglycoside, centellasapogenol A and centellasaponin A, from Centella asiatica (Gotu Kola). Heterocycles 55 1499-1504... 

Matsuda H, Morikawa T, Ueda H, Yoshikawa M (2001) Medical foodstuffs. XXVII. Saponin constitutes of gotu kola(2) structures of new ursane-and oleanane-type triterpene oligogly-cosidase, centell. Chem Pharm Bull 49 1368-1371... 

Gotu kola (Brahmi) Centella asiatica Plant Creams... 

United States, various gotu kola leaf preparations or cmde leaves are sold as dietary supplements in the form of tablets, capsules, tincture, standardized extracts, tea, and so on, used for memory improvement topically for the treatment of wounds (weiss wren). 

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