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Glycerol phosphate acyltransferase

Esterification of glycerol 3-phosphate with a long-chain fatty acid produces a strongly amphipathic lysophosphatidate (enzyme glycerol-3-phosphate acyltransferase 2.3.1.15). In this reaction, an acyl residue is transferred from the activated precursor acyl-CoA to the hydroxy group at C-1. [Pg.170]

H.S. Sul and D. Wang, Nutritional and hormonal regulation of enzymes in fat synthesis Studies on fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription, Annu. Rev. Nutr., 1998, 18, 331-351. [Pg.303]

L.E. Hammond, P.A. Gallagher, and S. Wang, et al., Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition. Mol. Cell. Biol., 2002, 22, 8204-8214. [Pg.309]

CTP phosphocholine cytidylyltransferase (3) glycerol kinase (4) acyl-CoA glycerol-3-phosphate acyltransferase (5) acyl-CoA acyl glycerol-3-phosphate acyltransferase (6) phosphatidic acid phosphatase (7) CDP-choline diacylglycerol phosphocholine transferase. [Pg.403]

Since phosphatidic acid serves as a precursor of phospholipids, galactolipids, and TGs, it is not surprising that its own synthesis has been reported in four plant compartments plastids, ER, mitochondria, and Golgi bodies. In each case, esterification of the first acyl group to the in-1 position of glycerol-3-phosphate is catalyzed by glycerol-3-phosphate acyltransferase. Lysophosphatidic acid acyltransferase then completes the synthesis by acylating the sn-2 position. However, plastidial and extraplastidial acyltransferases show distinct differences in structure and specificity. Analysis of these differences and the different compositions of plastid and non-plastid membranes led to the prokaryotic/ eukaryotic two-pathway scheme for plant lipid synthesis shown in Fig. 3. [Pg.104]

In the plastids, acyltransferases provide a direct route for entrance of acyl groups from ACP to membrane lipids. Since this is the standard pathway for phosphatidic acid synthesis in E. coli and cyanobacteria, both the enzymes of phosphatidic acid synthesis in plastids and the glycerolipid backbones they produce are termed prokaryotic . In both chloroplasts and non-green plastids, the glycerol-3-phosphate acyltransferase is a soluble enzyme that, unlike the E. coli enzyme, shows preference for 18 1-ACP over 16 0-ACP. The lysophosphatidic acid acyltransferase, which is a component of the inner envelope of plastids, is extremely selective for 16 0-ACP. The presence of a 16-carbon fatty acid at the... [Pg.106]

Altered lauric acid distribution in TG 1 -acyl-glycerol-3-phosphate acyltransferase Coconut Rapeseed... [Pg.123]

Altered cold tolerance Acyl-ACP glycerol-3-phosphate acyltransferase E. coliy squash, Arabidopsis Tobacco, Arabidopsis... [Pg.123]

Mouse Gpatl Glycerol-3-phosphate acyltransferase 1 Lower weight gain, decreased hepatic TG... [Pg.216]

Jain, R.K., M. Coffey, K. Lai, A. Kumar, and S.L. MacKenzie. 2000. Enhancement of seed oil content hy expression of glycerol-3-phosphate acyltransferase genes. Biochem. Soc. Trans. 28 958-961. [Pg.17]

Zheng, Z., Xia, Q., Dauk, M., Shen, W., Selvaraj, G., and Zou, J. Arabidopsis AtGPATl, a member of the membrane-bound glycerol-3-phosphate acyltransferase gene family, is essential for tapetum differentiation and male fertility. Plant Cell 15, 1872-1887, 2003. [Pg.31]

Lewin, T.M., Wang, R, and Coleman, R.A. Analysis of amino acid motifs diagnostic for the s -glycerol-3-phosphate acyltransferase reaction. Biochemistry, 5764—5771, 1999. [Pg.31]

P ADP -I- ]sn-glycerol-3-phosphate acyltransferase]phosphate S ATP -I- ]sn-glycerol-3-phosphate acyltransferase] <4> (Reversibility <4>... [Pg.467]

Park, H. Kaushik, V.K. Constant, S. Prentki, M. Przybytkowski, E. Ruder-man, N.B. Saha, A.K. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J. Biol. Chem., 277, 32571-32577 (2002)... [Pg.476]

Muoio, D.M. Seefeld, K. Witters, L.A. Coleman, R.A. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem. J., 338, 783-791 (1999)... [Pg.477]

See other pages where Glycerol phosphate acyltransferase is mentioned: [Pg.832]    [Pg.43]    [Pg.169]    [Pg.229]    [Pg.732]    [Pg.255]    [Pg.1485]    [Pg.438]    [Pg.330]    [Pg.508]    [Pg.528]    [Pg.529]    [Pg.26]    [Pg.244]    [Pg.219]    [Pg.106]    [Pg.107]    [Pg.242]    [Pg.256]    [Pg.409]    [Pg.572]    [Pg.206]    [Pg.551]    [Pg.7]    [Pg.8]    [Pg.27]    [Pg.467]    [Pg.467]    [Pg.479]    [Pg.486]   
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Acyltransferase

Acyltransferases

Glycerol-3-phosphate

Glycerol-3-phosphate acyltransferase GPAT)

Glycerol-3-phosphate acyltransferase assay

Glycerol-3-phosphate acyltransferase, reaction catalyzed

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